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利用 INTERGROWTH-21 特定胎龄标准评估英国的出生体重社会梯度。

Social gradient of birthweight in England assessed using the INTERGROWTH-21 gestational age-specific standard.

机构信息

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.

Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.

出版信息

Arch Dis Child Fetal Neonatal Ed. 2019 Sep;104(5):F486-F492. doi: 10.1136/archdischild-2018-315295. Epub 2018 Nov 21.

Abstract

OBJECTIVE

To determine the socioeconomic gradient of birthweights in England with reference to the prescriptive INTERGROWTH-21 Birthweight Standard.

DESIGN

National cross-sectional study using data from Hospital Episode Statistics.

SETTING

National Health Service in England.

PARTICIPANTS

All singleton babies, live born between 34 weeks' gestation and 42 weeks' gestation, between 1 April 2011 and 31 March 2012.

MAIN OUTCOME MEASURES

Birthweight distribution of babies with a birthweight of <10th centile or >90th centile, that is, small for gestational age (SGA) or large for gestational age (LGA) using Index of Multiple Deprivation quintiles as a proxy for socioeconomic status.

RESULTS

Of 508 230 babies born alive between 1 April 2011 and 31 March 2012, 38 838 (7.6%) were SGA and 81 026 (15.9%) were LGA. Median birthweight was 3405 g, median z-score was 0.25 (SD 1.06). Birthweight z-score demonstrated a social gradient, from 0.26 (SD 1.1) in the most deprived areas to 0.53 (1.0) in the least deprived. Women in the most deprived areas were twice as likely to have SGA babies using the INTERGROWTH-21 chart (OR 1.94; 95% CI 1.87 to 2.01) compared with those in the least deprived areas. If all women had the same rate of SGA equivalent to those living in the least deprived areas, approximately 12 410 (30%) fewer babies would be born SGA in England each year.

CONCLUSIONS

This study gives a measure of the social gradient in singleton SGA and LGA babies across England using an international standard of newborn size at birth.

摘要

目的

参照 INTERGROWTH-21 出生体重标准,确定英国出生体重的社会经济梯度。

设计

利用医院出院统计数据进行的全国性横断面研究。

设置

英国国民保健制度。

参与者

2011 年 4 月 1 日至 2012 年 3 月 31 日期间,胎龄 34 周至 42 周之间、单胎活产的所有婴儿。

主要观察指标

使用多因素剥夺指数五分位数作为社会经济地位的替代指标,根据出生体重<第 10 百分位数或>第 90 百分位数,即小于胎龄儿(SGA)或大于胎龄儿(LGA),来评估婴儿的出生体重分布情况。

结果

在 2011 年 4 月 1 日至 2012 年 3 月 31 日期间,508230 名活产婴儿中,38838 名(7.6%)为 SGA,81026 名(15.9%)为 LGA。出生体重中位数为 3405g,出生体重 z 评分中位数为 0.25(SD 1.06)。出生体重 z 评分呈社会梯度分布,从最贫困地区的 0.26(SD 1.1)到最富裕地区的 0.53(SD 1.0)。与最富裕地区的女性相比,处于最贫困地区的女性使用 INTERGROWTH-21 图表,SGA 婴儿的可能性是后者的两倍(OR 1.94;95%CI 1.87 至 2.01)。如果所有女性的 SGA 发生率与最富裕地区的女性相同,那么英国每年 SGA 婴儿的出生人数将减少约 12410 人(30%)。

结论

本研究使用国际新生儿出生体重标准,衡量了英国单胎 SGA 和 LGA 婴儿的社会经济梯度。

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