Dept of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark.
Dept of Gynaecology and Obstetrics, Hvidovre Hospital, Hvidovre, Denmark.
Eur Respir J. 2019 Feb 14;53(2). doi: 10.1183/13993003.00597-2018. Print 2019 Feb.
Asthma has been linked with prolonged time to pregnancy. Our aim was to explore a possible association between asthma and need for fertility treatment among women with live births.All women enrolled in the Management of Asthma during Pregnancy (MAP) programme at Hvidovre Hospital, Denmark were each matched with the next three consecutive women giving birth at Hvidovre Hospital. Information from the Danish National Assisted Reproductive Technology (ART) registry was cross-linked with the Danish Medical Birth registry to identify live births. The primary outcome of interest was births following fertility treatment.Our sample comprised pregnancies from asthmatic mothers (n=932, described as "cases") and non-asthmatic mothers (n=2757, described as "controls"), with 12% (n=114) and 8% (n=212), respectively, having had fertility treatment (OR 1.67, 95% CI 1.32-2.13; p<0.001). This association remained statistically significant after adjusting for confounders, including body mass index (OR 1.31, 95% CI 1.00-1.70; p=0.047). In women ≥35 years, 25% of cases (n=63) and 13% of controls (n=82) received fertility treatment (OR 2.12, 95% CI 1.47-3.07; p<0.001), which also remained statistically significant after adjusting for confounders (OR 1.65, 95% CI 1.11-2.46; p=0.013).A higher proportion of the births from asthmatic mothers involved fertility treatment compared to non-asthmatic mothers, not least among women aged ≥35 years.
哮喘与妊娠时间延长有关。我们的目的是探讨哮喘与活产妇女生育治疗需求之间的可能关联。
丹麦 Hvidovre 医院的管理妊娠哮喘（MAP）项目中所有入组的女性，均与 Hvidovre 医院同期分娩的下一个连续三位女性进行匹配。丹麦国家辅助生殖技术（ART）登记处的信息与丹麦医疗出生登记处进行交叉链接，以确定活产。主要观察结局为生育治疗后的分娩。
我们的样本包括哮喘母亲（n=932，描述为“病例”）和非哮喘母亲（n=2757，描述为“对照”）的妊娠，其中 12%（n=114）和 8%（n=212）分别接受了生育治疗（OR 1.67，95%CI 1.32-2.13；p<0.001）。调整混杂因素后，包括体重指数（OR 1.31，95%CI 1.00-1.70；p=0.047），这种关联仍然具有统计学意义。在年龄≥35 岁的女性中，25%的病例（n=63）和 13%的对照组（n=82）接受了生育治疗（OR 2.12，95%CI 1.47-3.07；p<0.001），调整混杂因素后仍然具有统计学意义（OR 1.65，95%CI 1.11-2.46；p=0.013）。
与非哮喘母亲相比，哮喘母亲的分娩中生育治疗的比例更高，尤其是在年龄≥35 岁的女性中。
