比较琥珀酰胆碱不同剂量方案用于快速诱导插管时的功能结局。

Comparing The Functional Outcome Of Different Dose Regimes Of Succinylcholine When Used For Rapid Induction And Intubation.

作者信息

Ahmad Munir, Khan Nadeem Ahmed, Furqan Aamir

机构信息

Department of Anaesthesia, Nishtar Medical University Multan, Pakistan.

出版信息

J Ayub Med Coll Abbottabad. 2018 Jul-Sep;30(3):401-404.

PMID:30465374

Abstract

BACKGROUND

This study was conducted to compare outcomes of different doses of succinylcholine, in terms of intubation condition, onset of action, duration of action and abdominal fasciculation.

METHODS

Thus, randomized control trial was conducted in the department of anaesthesia and ICU, Nishter Hospital Multan from April 2016 to November 2016. A total number of 60 patients with ASA status I and II were enrolled. All patients were divided into three groups by lottery method. Data was entered and analysed by computer software SPSS version 23.2. Descriptive variables like age and onset of action were presented as mean and SD and continues statistics like gender, abdominal fasciculation and incubation condition were presented as frequency and percentages. Chi square test and one-way ANOVA was applied to see effect modification and significance of results. The p-value 0.05 was considered as significant.

RESULTS

A Total number of 60 patients included in this study and all were female. The mean age of the patients was 28.15±4.5 years. The main outcome variables of this study were the fasciculation, satisfactory intubation, onset time (seconds) and duration of action (in minutes). In group (A) 1mg, abdominal fasciculation was found 80%, 85% and 75% in group A, B, C respectively. It was also observed that satisfactory intubation was found 90%, 80% and 30% in three groups respectively. The mean onset time was 50.95±4.6, 70.7±5.66 and 94.15±8.73 seconds in three groups respectively. Similarly, the mean duration of action was 16.1±3.76, 13.55±3.01 and 8±2.05 minutes respectively.

CONCLUSIONS

Results of our clinical trial suggest that succinylcholine in low doses shorter duration of action and low rate of abdominal fasciculation which is desirable for rapid induction but onset of action is prolonged and intubation conditions were not satisfactory predominantly. So, we concluded that low doses of succnylcholine are not so much beneficial that I can replace full doses of succinylcholine when used for rapid induction and intubation.

摘要

背景

本研究旨在比较不同剂量琥珀酰胆碱在插管条件、起效时间、作用持续时间和腹部肌束震颤方面的效果。

方法

因此，于2016年4月至2016年11月在木尔坦尼什特医院麻醉与重症监护科进行了一项随机对照试验。共纳入60例ASA分级为I级和II级的患者。所有患者通过抽签法分为三组。数据通过计算机软件SPSS 23.2录入和分析。描述性变量如年龄和起效时间以均值和标准差表示，连续性统计变量如性别、腹部肌束震颤和插管条件以频率和百分比表示。应用卡方检验和单因素方差分析来观察结果的效应修正和显著性。p值<0.05被认为具有显著性。

结果

本研究共纳入60例患者，均为女性。患者的平均年龄为28.15±4.5岁。本研究的主要结局变量为肌束震颤、满意插管、起效时间（秒）和作用持续时间（分钟）。在A组（1mg）中，A、B、C组的腹部肌束震颤发生率分别为80%、85%和75%。还观察到三组的满意插管率分别为90%、80%和30%。三组的平均起效时间分别为50.95±4.6秒、70.7±5.66秒和94.15±8.73秒。同样，平均作用持续时间分别为16.1±3.76分钟、13.55±3.01分钟和8±2.05分钟。