Sosa Iglesias Venus, van Hoof Stefan J, Vaniqui Ana, Schyns Lotte Ejr, Lieuwes Natasja, Yaromina Ala, Spiegelberg Linda, Groot Arjan J, Verhaegen Frank, Theys Jan, Dubois Ludwig, Vooijs Marc
1 Department of Radiotherapy, GROW-School for Oncology & Developmental Biology, Maastricht University Medical Centre , Maastricht , The Netherlands.
Br J Radiol. 2019 Mar;92(1095):20180476. doi: 10.1259/bjr.20180476. Epub 2018 Nov 30.
: An orthotopic non-small cell lung cancer model in NMRI-nude mice was established to investigate the complementary information acquired from 80 kVp microcone-beam CT (micro-CBCT) and bioluminescence imaging (BLI) using different angles and filter settings. Different micro-CBCT-based radiation-delivery plans were evaluated based on their dose-volume histogram metrics of tumor and organs at risk to select the optimal treatment plan.
: H1299 cell suspensions injected directly into the lung render exponentially growing single tumor nodules whose CBCT-based volume quantification strongly correlated with BLI-integrated intensity. Parallel-opposed single angle beam plans through a single lung are preferred for smaller tumors, whereas for larger tumors, plans that spread the radiation dose across healthy tissues are favored.
: Closely mimicking a clinical setting for lung cancer with highly advanced preclinical radiation treatment planning is possible in mice developing orthotopic lung tumors.
: BLI and CBCT imaging of orthotopic lung tumors provide complementary information in a temporal manner. The optimal radiotherapy plan is tumor volume-dependent.
在NMRI-裸鼠中建立原位非小细胞肺癌模型，以研究使用不同角度和滤过设置从80 kVp微锥束CT（micro-CBCT）和生物发光成像（BLI）获得的互补信息。基于肿瘤和危及器官的剂量体积直方图指标评估不同的基于micro-CBCT的放射治疗计划，以选择最佳治疗计划。
直接注入肺内的H1299细胞悬液产生指数生长的单个肿瘤结节，其基于CBCT的体积定量与BLI积分强度密切相关。对于较小的肿瘤，通过单肺的平行相对单角度束计划是首选，而对于较大的肿瘤，则倾向于将放射剂量分布在健康组织上的计划。
在发生原位肺肿瘤的小鼠中，通过高度先进的临床前放射治疗计划密切模拟肺癌的临床情况是可能的。
原位肺肿瘤的BLI和CBCT成像以时间方式提供互补信息。最佳放疗计划取决于肿瘤体积。
