临床研究血卟啉单甲醚光动力疗法治疗婴儿面部葡萄酒色斑。
Clinical study on hemoporfin PDT for infant facial port-wine stains.
机构信息
Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China.
出版信息
Photodiagnosis Photodyn Ther. 2019 Mar;25:106-110. doi: 10.1016/j.pdpdt.2018.09.012. Epub 2018 Nov 19.
OBJECTIVE
To observe the clinical efficacy and therapeutic response of Hemoporfin photodynamic therapy (PDT) for infant facial port-wine stains (PWS).
METHOD
Hemoporfin PDT was used to treat 100 cases of infant facial PWS. After receiving Hemoporfin skin test, the cases with a negative skin test result were intravenously injected with Hemippofen (5 mg/kg) and irradiated under 532 nm LED green light. After treatment, a follow-up visit was paid through WeChat and Dermlink PWS consulting platform, in order to observe the therapeutic response and clinical efficacy.
RESULT
The follow-up visit showed an effective rate of 98%, including 85 cases of itching (85%), 100 cases of edema (100%), 89 cases of purpura-like change (89%), 33 cases of crust (33%), 2 cases of hyperpigmentation (2%) and 2 cases of scars (2%), with no allergy and other systematic adverse reaction.
CONCLUSION
Hemoporfin PDT has a high clinical efficacy and response rate in treating infant facial PWS, with slight adverse reactions.
目的
观察血卟啉光动力疗法（PDT）治疗婴幼儿面部葡萄酒色斑（PWS）的临床疗效和治疗反应。
方法
采用血卟啉 PDT 治疗 100 例婴幼儿面部 PWS。在进行血卟啉皮肤试验后，对皮肤试验结果阴性的病例静脉注射血卟啉（5mg/kg），并在 532nm LED 绿光下进行照射。治疗后，通过微信和 Dermlink PWS 咨询平台进行随访，以观察治疗反应和临床疗效。
结果
随访显示有效率为 98%，其中瘙痒 85 例（85%）、水肿 100 例（100%）、紫癜样改变 89 例（89%）、结痂 33 例（33%）、色素沉着 2 例（2%）和瘢痕 2 例（2%），无过敏等全身不良反应。
结论
血卟啉 PDT 治疗婴幼儿面部 PWS 临床疗效高，反应率高，不良反应轻微。
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