Laboratory of the Division of Dermatology, University Hospital, Ribeirão Preto Medical School, Avenida Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.
Laboratory of the Division of Dermatology, University Hospital, Ribeirão Preto Medical School, Avenida Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.
J Trace Elem Med Biol. 2019 Jan;51:31-35. doi: 10.1016/j.jtemb.2018.09.005. Epub 2018 Sep 24.
Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune bullous diseases; they are endemic in the northeastern region of the state of São Paulo, Southeastern Brazil. Patients' copper (Cu), zinc (Zn), and selenium (Se) metabolic deficiencies have already been associated with PV pathogenesis in the Middle East but not in Brazil. Lead (Pb), Cu, Zn, and Se concentrations were determined in whole blood or serum samples obtained from 56 PV patients, 62 PF patients, and 135 healthy controls from the endemic region and compared. The PV patients had higher (above the reference values) Pb and lower Zn levels as compared to controls. Both the PV and the PF patients presented decreased Se levels as compared to controls. The PV, PF, and control groups did not differ in terms of Cu concentration. These results indicate that high Pb blood levels are related with environmental contamination and consequently with PV pathogenesis. Moreover, Zn and Se depletion, observed in the PV patients and in the PV and the PF patients, respectively, may result from metabolic consumption verified in chronic diseases.
落叶型天疱疮（PF）和寻常型天疱疮（PV）是自身免疫性大疱性疾病；它们在巴西东南部圣保罗州的东北部地区流行。中东地区已经发现患者的铜（Cu）、锌（Zn）和硒（Se）代谢缺陷与 PV 的发病机制有关，但在巴西尚未发现。从流行地区采集了 56 名 PV 患者、62 名 PF 患者和 135 名健康对照者的全血或血清样本，测定了其中的铅（Pb）、Cu、Zn 和 Se 浓度并进行了比较。与对照组相比，PV 患者的 Pb 水平较高（高于参考值），Zn 水平较低。与对照组相比，PV 和 PF 患者的 Se 水平均降低。PV、PF 和对照组之间 Cu 浓度没有差异。这些结果表明，高 Pb 血水平与环境污染有关，从而与 PV 的发病机制有关。此外，PV 患者中观察到 Zn 和 Se 耗竭，而在 PV 和 PF 患者中分别观察到 Se 耗竭，这可能是由慢性疾病中代谢消耗引起的。
