Time to reconsider urate: Neuroprotective potential may prevail on cardiovascular risk in animal models and clinical trials.
作者信息
Petruzzo Martina, Moccia Marcello
机构信息
Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.
Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.
出版信息
EBioMedicine. 2018 Nov;37:5-6. doi: 10.1016/j.ebiom.2018.10.073. Epub 2018 Nov 19.
Abstract
摘要
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Time to reconsider urate: Neuroprotective potential may prevail on cardiovascular risk in animal models and clinical trials.是时候重新审视尿酸了：在动物模型和临床试验中，神经保护潜力可能超过心血管风险。
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Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo.尿酸在细胞培养中可保护神经元免受兴奋性毒性和代谢损伤，在体内可保护神经元免受局灶性缺血性脑损伤。
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Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.尿酸与血压在小鼠和早期帕金森病患者中的分离。
EBioMedicine. 2018 Nov;37:259-268. doi: 10.1016/j.ebiom.2018.10.039. Epub 2018 Nov 8.
2
Hyperuricemia and endothelial function: From molecular background to clinical perspectives.高尿酸血症与血管内皮功能：从分子基础到临床观点。
Atherosclerosis. 2018 Nov;278:226-231. doi: 10.1016/j.atherosclerosis.2018.10.007. Epub 2018 Oct 6.
3
Association between serum uric acid level and multiple system atrophy: A meta-analysis.血清尿酸水平与多系统萎缩之间的关联：一项荟萃分析。
Clin Neurol Neurosurg. 2018 Jun;169:16-20. doi: 10.1016/j.clineuro.2018.03.023. Epub 2018 Mar 27.
4
Targeting urate to reduce oxidative stress in Parkinson disease.以尿酸为靶点降低帕金森病中的氧化应激。
Exp Neurol. 2017 Dec;298(Pt B):210-224. doi: 10.1016/j.expneurol.2017.06.017. Epub 2017 Jun 13.
5
Urate as a Marker of Risk and Progression of Neurodegenerative Disease.尿酸作为神经退行性疾病风险和进展的标志物。
Neurotherapeutics. 2017 Jan;14(1):148-153. doi: 10.1007/s13311-016-0497-4.
6
Uric acid in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.复发缓解型多发性硬化症中的尿酸：一项为期2年的纵向研究。
J Neurol. 2015;262(4):961-7. doi: 10.1007/s00415-015-7666-y. Epub 2015 Feb 12.
7
Associated Inosine to interferon: results of a clinical trial in multiple sclerosis.肌苷与干扰素联合使用：多发性硬化症临床试验结果
Acta Neurol Scand. 2015 Jun;131(6):405-10. doi: 10.1111/ane.12333. Epub 2014 Oct 14.
8
Is serum uric acid related to non-motor symptoms in de-novo Parkinson's disease patients?血清尿酸与首发帕金森病患者的非运动症状有关吗？
Parkinsonism Relat Disord. 2014 Jul;20(7):772-5. doi: 10.1016/j.parkreldis.2014.03.016. Epub 2014 Mar 25.
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Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial.尿酸治疗急性脑卒中患者的安全性和有效性（URICO-ICTUS）：一项随机、双盲、2b/3 期试验。
Lancet Neurol. 2014 May;13(5):453-60. doi: 10.1016/S1474-4422(14)70054-7. Epub 2014 Apr 2.
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Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial.用肌苷增加帕金森病患者血清和脑脊液中的尿酸：一项随机临床试验。
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