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Time to reconsider urate: Neuroprotective potential may prevail on cardiovascular risk in animal models and clinical trials.

作者信息

Petruzzo Martina, Moccia Marcello

机构信息

Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.

Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.

出版信息

EBioMedicine. 2018 Nov;37:5-6. doi: 10.1016/j.ebiom.2018.10.073. Epub 2018 Nov 19.

DOI:10.1016/j.ebiom.2018.10.073
PMID:30467010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6286264/
Abstract
摘要

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Time to reconsider urate: Neuroprotective potential may prevail on cardiovascular risk in animal models and clinical trials.是时候重新审视尿酸了：在动物模型和临床试验中，神经保护潜力可能超过心血管风险。
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2
Uric acid: neuroprotective or neurotoxic?尿酸：具有神经保护作用还是神经毒性？
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Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3β/Nrf2/GCLC pathways.尿酸对肌萎缩侧索硬化症相关突变 hSOD1 细胞和果蝇模型的神经保护作用：通过激活 Akt/GSK3β/Nrf2/GCLC 通路影响 GSH 合成。
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4
Uric acid and neuroprotection.尿酸与神经保护
Stroke. 2008 Aug;39(8):e126. doi: 10.1161/STROKEAHA.108.524462. Epub 2008 Jun 19.
5
Targeting urate to reduce oxidative stress in Parkinson disease.以尿酸为靶点降低帕金森病中的氧化应激。
Exp Neurol. 2017 Dec;298(Pt B):210-224. doi: 10.1016/j.expneurol.2017.06.017. Epub 2017 Jun 13.
6
Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo.尿酸在细胞培养中可保护神经元免受兴奋性毒性和代谢损伤，在体内可保护神经元免受局灶性缺血性脑损伤。
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Caffeine and uric acid mediate glutathione synthesis for neuroprotection.咖啡因和尿酸通过调节谷胱甘肽合成发挥神经保护作用。
Neuroscience. 2011 May 5;181:206-15. doi: 10.1016/j.neuroscience.2011.02.047. Epub 2011 Mar 1.
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Uric acid demonstrates neuroprotective effect on Parkinson's disease mice through Nrf2-ARE signaling pathway.尿酸通过Nrf2-ARE信号通路对帕金森病小鼠表现出神经保护作用。
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Neuroprotective effects of urate are mediated by augmenting astrocytic glutathione synthesis and release.尿酸的神经保护作用是通过增强星形胶质细胞谷胱甘肽的合成与释放来介导的。
Neurobiol Dis. 2015 Oct;82:574-579. doi: 10.1016/j.nbd.2015.08.022. Epub 2015 Sep 1.
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Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease.尿酸抑制小胶质细胞活化，从而保护脂多糖诱导的帕金森病模型中的神经元。
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引用本文的文献

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Lower preoperative serum uric acid level may be a risk factor for postoperative delirium in older patients undergoing hip fracture surgery: a matched retrospective case-control study.术前血清尿酸水平较低可能是老年髋部骨折手术患者术后谵妄的危险因素：一项匹配的回顾性病例对照研究。
BMC Anesthesiol. 2022 Sep 7;22(1):282. doi: 10.1186/s12871-022-01824-0.
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Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS.孟德尔随机化研究表明，血清尿酸水平与 MS 风险之间不存在因果关系。
Neurol Neuroimmunol Neuroinflamm. 2020 Nov 19;8(1). doi: 10.1212/NXI.0000000000000920. Print 2021 Jan.

本文引用的文献

1
Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.尿酸与血压在小鼠和早期帕金森病患者中的分离。
EBioMedicine. 2018 Nov;37:259-268. doi: 10.1016/j.ebiom.2018.10.039. Epub 2018 Nov 8.
2
Hyperuricemia and endothelial function: From molecular background to clinical perspectives.高尿酸血症与血管内皮功能：从分子基础到临床观点。
Atherosclerosis. 2018 Nov;278:226-231. doi: 10.1016/j.atherosclerosis.2018.10.007. Epub 2018 Oct 6.
3
Association between serum uric acid level and multiple system atrophy: A meta-analysis.血清尿酸水平与多系统萎缩之间的关联：一项荟萃分析。
Clin Neurol Neurosurg. 2018 Jun;169:16-20. doi: 10.1016/j.clineuro.2018.03.023. Epub 2018 Mar 27.
4
Targeting urate to reduce oxidative stress in Parkinson disease.以尿酸为靶点降低帕金森病中的氧化应激。
Exp Neurol. 2017 Dec;298(Pt B):210-224. doi: 10.1016/j.expneurol.2017.06.017. Epub 2017 Jun 13.
5
Urate as a Marker of Risk and Progression of Neurodegenerative Disease.尿酸作为神经退行性疾病风险和进展的标志物。
Neurotherapeutics. 2017 Jan;14(1):148-153. doi: 10.1007/s13311-016-0497-4.
6
Uric acid in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.复发缓解型多发性硬化症中的尿酸：一项为期2年的纵向研究。
J Neurol. 2015;262(4):961-7. doi: 10.1007/s00415-015-7666-y. Epub 2015 Feb 12.
7
Associated Inosine to interferon: results of a clinical trial in multiple sclerosis.肌苷与干扰素联合使用：多发性硬化症临床试验结果
Acta Neurol Scand. 2015 Jun;131(6):405-10. doi: 10.1111/ane.12333. Epub 2014 Oct 14.
8
Is serum uric acid related to non-motor symptoms in de-novo Parkinson's disease patients?血清尿酸与首发帕金森病患者的非运动症状有关吗？
Parkinsonism Relat Disord. 2014 Jul;20(7):772-5. doi: 10.1016/j.parkreldis.2014.03.016. Epub 2014 Mar 25.
9
Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial.尿酸治疗急性脑卒中患者的安全性和有效性（URICO-ICTUS）：一项随机、双盲、2b/3 期试验。
Lancet Neurol. 2014 May;13(5):453-60. doi: 10.1016/S1474-4422(14)70054-7. Epub 2014 Apr 2.
10
Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial.用肌苷增加帕金森病患者血清和脑脊液中的尿酸：一项随机临床试验。
JAMA Neurol. 2014 Feb;71(2):141-50. doi: 10.1001/jamaneurol.2013.5528.