氯化镍对链脲佐菌素诱导的大鼠糖尿病的影响。
Effect of nickel chloride on streptozotocin-induced diabetes in rats.
作者信息
Novelli E L, Rodrigues N L, Ribas B O
机构信息
Departamento de Bioquímica, Universidade Estadual Paulista, São Paulo, Brazil.
出版信息
Can J Physiol Pharmacol. 1988 May;66(5):663-5. doi: 10.1139/y88-104.
The potential of nickel chloride to prevent streptozotocin-induced hyperglycemia was tested in rats in vivo. To induce diabetes, streptozotocin (100 mg/kg body weight) was injected as a single dose. Streptozotocin treatment resulted in a significant decrease in plasma insulin and ceruloplasmin, and pancreatic Cu, protein, and Cu-Zn superoxide dismutase activity. In rats treated with nickel chloride (10 mg/kg body weight) and streptozotocin, these values were comparable with those observed in control rats. The results indicate that nickel chloride injected before streptozotocin prevented streptozotocin-induced hyperglycemia, and suggest that the protective effect was related to Cu-Zn superoxide dismutase activity, mediated by copper.
在大鼠体内测试了氯化镍预防链脲佐菌素诱导的高血糖的潜力。为诱导糖尿病，以单剂量注射链脲佐菌素（100毫克/千克体重）。链脲佐菌素治疗导致血浆胰岛素和铜蓝蛋白以及胰腺铜、蛋白质和铜锌超氧化物歧化酶活性显著降低。在用氯化镍（10毫克/千克体重）和链脲佐菌素治疗的大鼠中，这些值与在对照大鼠中观察到的值相当。结果表明，在链脲佐菌素之前注射氯化镍可预防链脲佐菌素诱导的高血糖，并表明保护作用与由铜介导的铜锌超氧化物歧化酶活性有关。
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