Blume Martin, Seeber Frank
NG2 - Metabolism of Microbial Pathogens, Robert Koch-Institute, Berlin, Germany.
FG16 - Mycotic and Parasitic Agents and Mycobacteria, Robert Koch-Institute, Berlin, Germany.
F1000Res. 2018 Oct 30;7. doi: 10.12688/f1000research.16021.1. eCollection 2018.
is an obligate intracellular parasite belonging to the phylum Apicomplexa that infects all warm-blooded animals, including humans. can replicate in every nucleated host cell by orchestrating metabolic interactions to derive crucial nutrients. In this review, we summarize the current status of known metabolic interactions of with its host cell and discuss open questions and promising experimental approaches that will allow further dissection of the host-parasite interface and discovery of ways to efficiently target both tachyzoite and bradyzoite forms of , which are associated with acute and chronic infection, respectively.
是一种专性细胞内寄生虫,属于顶复门,可感染包括人类在内的所有温血动物。它能够通过精心安排代谢相互作用以获取关键营养物质,从而在每个有核宿主细胞中进行复制。在本综述中,我们总结了已知的与其宿主细胞代谢相互作用的现状,并讨论了一些尚未解决的问题以及有前景的实验方法,这些将有助于进一步剖析宿主 - 寄生虫界面,并找到有效靶向速殖子和缓殖子形式的方法,它们分别与急性和慢性感染相关。