a Departments of Obstetrics & Gynecology , Pediatrics, Psychiatry and Quantitative Health Sciences, University of Massachusetts Medical School/UMass Memorial Health Care , Worcester , MA , USA.
b Sage Therapeutics, Inc. , Cambridge , MA , USA.
Curr Med Res Opin. 2019 Mar;35(3):383-393. doi: 10.1080/03007995.2018.1552039. Epub 2018 Dec 13.
Postpartum depression (PPD) is the most common medical complication of childbirth. PPD can be disabling, with potential negative effects on maternal health-related quality-of-life (HRQoL) as well as on children and partners. The objective of this study was to systematically review and summarize recently published literature describing the humanistic burden of PPD on affected women, their children, and partners.
Databases including Embase, MEDLINE, and PsycINFO, as well as conference proceedings were searched for keywords related to PPD. Searches were initially conducted in February 2017 and restricted to the prior 5 years for databases and the prior 2 years for conference proceedings. Searches were updated in February 2018. Two researchers independently reviewed 1154 unique records according to pre-defined inclusion and exclusion screening criteria.
Forty-eight studies were identified; over 40 studies assessed the effects of PPD on children of affected mothers, with many demonstrating a negative association with elements of parenting and childhood development. Furthermore, five studies that evaluated the effects of PPD symptoms on partners suggested that certain aspects of their relationships were negatively affected. Partners of affected women also experienced greater levels of their own stress, anxiety, and depression compared with partners of women without PPD symptoms. Despite limited data on HRQoL among women with PPD symptoms (four studies), a negative impact on physical and mental sub-scales was observed.
Findings suggest that PPD symptoms have a substantial humanistic burden on affected mothers as well as on their children and partners.
产后抑郁症（PPD）是分娩后最常见的医学并发症。PPD 可能导致残疾，对产妇健康相关生活质量（HRQoL）以及对儿童和伴侣产生潜在的负面影响。本研究的目的是系统地回顾和总结最近发表的文献，描述 PPD 对受影响的女性、她们的孩子和伴侣的人文负担。
我们搜索了 Embase、MEDLINE 和 PsycINFO 等数据库以及会议记录，使用与 PPD 相关的关键词进行搜索。搜索最初于 2017 年 2 月进行，并对数据库的检索范围限制为过去 5 年，对会议记录的检索范围限制为过去 2 年。2018 年 2 月进行了更新。两名研究人员根据预先确定的纳入和排除筛选标准，独立审查了 1154 条独特的记录。
确定了 48 项研究；超过 40 项研究评估了 PPD 对受影响母亲的孩子的影响，其中许多研究表明 PPD 与育儿和儿童发展的某些方面存在负相关。此外，五项评估 PPD 症状对伴侣影响的研究表明，他们关系的某些方面受到负面影响。与没有 PPD 症状的女性的伴侣相比，受影响女性的伴侣也经历了更高水平的自身压力、焦虑和抑郁。尽管有关患有 PPD 症状的女性的 HRQoL 的数据有限（四项研究），但观察到对身体和心理子量表的负面影响。
研究结果表明，PPD 症状对受影响的母亲及其子女和伴侣都有很大的人文负担。
