Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Psychol Med. 2019 Nov;49(15):2524-2532. doi: 10.1017/S003329171800346X. Epub 2018 Nov 23.
Sexual minority youth have elevated suicidal ideation and self-harm compared with heterosexual young people; however, evidence for mediating mechanisms is predominantly cross-sectional. Using a longitudinal design, we investigated self-esteem and depressive symptoms as mediators of increased rates of suicidal ideation or self-harm (SISH) among sexual minority youth, and the roles of childhood gender nonconformity (CGN) and sex as moderators of these relationships.
In total, 4274 youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort reported sexual orientation at age 15 years, and past-year SISH at age 20 years. Self-esteem and depressive symptoms were assessed at ages 17 and 18 years, respectively. CGN was measured at 30-57 months. Covariates included sociodemographic variables and earlier measures of mediator and outcome variables. Mediation pathways were assessed using structural equation modelling.
Sexual minority youth (almost 12% of the sample) were three times more likely than heterosexual youth to report past-year SISH (95% confidence interval 2.43-3.64) at 20 years. Two mediation pathways were identified: a single mediator pathway involving self-esteem and a multiple-mediated pathway involving self-esteem and depressive symptoms. Although CGN was associated with past-year SISH, it did not moderate any mediation pathways and there was no evidence for moderation by sex.
Lower self-esteem and increased depressive symptoms partly explain the increased risk for later suicidal ideation and self-harm in sexual minority youth. Preventive strategies could include self-esteem-enhancing or protecting interventions, especially in female sexual minority youth, and treatment of depression.
与异性恋年轻人相比,性少数青年的自杀意念和自残行为发生率较高;然而,中介机制的证据主要是横断面的。本研究采用纵向设计,调查了自尊和抑郁症状是否为性少数青年自杀意念或自残(SISH)发生率增加的中介机制,以及童年性别非典型(CGN)和性别的作用是否为这些关系的调节因素。
共有 4274 名来自阿冯纵向研究父母和儿童(ALSPAC)队列的青少年在 15 岁时报告了性取向,在 20 岁时报告了过去一年的 SISH。自尊和抑郁症状分别在 17 岁和 18 岁时评估。CGN 在 30-57 个月时测量。协变量包括社会人口统计学变量以及早期中介和结果变量的测量值。使用结构方程模型评估中介途径。
性少数青年(占样本的近 12%)在 20 岁时报告过去一年 SISH 的可能性是异性恋青年的三倍(95%置信区间 2.43-3.64)。确定了两种中介途径:一种是涉及自尊的单一中介途径,另一种是涉及自尊和抑郁症状的多重中介途径。尽管 CGN 与过去一年的 SISH 有关,但它并没有调节任何中介途径,也没有证据表明性别有调节作用。
较低的自尊和较高的抑郁症状部分解释了性少数青年以后自杀意念和自残风险增加的原因。预防策略可能包括增强或保护自尊的干预措施,特别是在女性性少数青年中,并治疗抑郁症。