Department of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie Institute- Oncology Centre, Gliwice Branch, Gliwice, Poland.
J Eur Acad Dermatol Venereol. 2019 Apr;33(4):637-642. doi: 10.1111/jdv.15357. Epub 2018 Dec 7.
Nail abnormalities after allogeneic haematopoietic stem cell transplantation procedure (alloHSCT) are often reported. Usually, they are related to chronic graft-versus-host disease (cGvHD). So far, only clinical manifestations of selected nail abnormalities have been described, without the presentation of dermoscopic images. In this article, we present morphologic and dermoscopic manifestations of potential non-infectious nail abnormalities in patients after alloHSCT procedure based on reviewed literature and our own experience with dermoscopic iconography. In majority of studies published till now, nail changes are not connected to severity of other cGvHD symptoms; however, e.g. the presence of pterygium inversum unguis may be an indicator of lung dysfunction. As nail changes may be an early sign of cGvHD and always present in association with other manifestations, routine clinical assessment should include nails examination. Knowledge of possible presentation of nail involvement after alloHSCT may be valuable for treating physician.
异基因造血干细胞移植（alloHSCT）术后常出现指甲异常。这些异常通常与慢性移植物抗宿主病（cGvHD）有关。迄今为止，仅描述了部分指甲异常的临床表现，而没有展示其皮肤镜图像。本文基于文献回顾和我们对皮肤镜图像的经验，介绍了 alloHSCT 术后潜在非传染性指甲异常的形态学和皮肤镜表现。在迄今为止发表的大多数研究中，指甲改变与其他 cGvHD 症状的严重程度无关；然而，例如，反向甲翼的存在可能是肺功能障碍的指标。由于指甲改变可能是 cGvHD 的早期迹象，并且总是与其他表现同时存在，因此常规临床评估应包括指甲检查。了解 alloHSCT 后指甲受累的可能表现可能对治疗医生有价值。
