Department of Emergency, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan; Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Laboratory of Research, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; Departments of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan.
Drug Alcohol Depend. 2019 Jan 1;194:264-270. doi: 10.1016/j.drugalcdep.2018.10.030. Epub 2018 Nov 15.
To evaluate the relationship of patients with a history of alcohol use disorders (AUD) and its diagnostic categories with risk of subsequent mesenteric ischemia in Taiwan.
A nationwide population-based cohort study was conducted using data from the Taiwan's National Health Insurance Research Database. We identified 73,583 patients hospitalized for AUD between 2001 and 2010, and matched each case with four comparison patients based on age, gender, Charlson comorbidity index, and the index date. Cox proportional hazard models were used to evaluate the risk of mesenteric ischemia between the AUD and non-AUD cohorts. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated.
Patients with AUD exhibited a significantly increased risk of developing mesenteric ischemia (HR = 2.25; 95% CI 1.92-2.64) compared with those with non-AUD after adjustment for patient sociodemographic, coexisting comorbid conditions, and hospital characteristics. Furthermore, a 2.29- and 2.17-fold higher risk of mesenteric ischemia was observed in patients with alcohol abuse/dependence (HR = 2.29; 95% CI 1.94-2.71) and alcoholic psychosis (HR = 2.17; 95% CI 1.72-2.73), respectively, than in non-AUD comparisons after covariate adjustment.
This study confirmed that the risk of mesenteric ischemia was significantly higher among patients with different diagnostic categories of AUD, particularly for those with alcohol abuse/dependence.
评估有酒精使用障碍（AUD）病史及其诊断类别的患者与台湾随后发生肠系膜缺血的风险之间的关系。
本研究采用来自台湾全民健康保险研究数据库的数据，进行了一项全国性基于人群的队列研究。我们确定了 2001 年至 2010 年间因 AUD 住院的 73583 例患者，并根据年龄、性别、Charlson 合并症指数和索引日期，为每个病例匹配了 4 名对照患者。使用 Cox 比例风险模型评估 AUD 和非 AUD 队列之间肠系膜缺血的风险。计算风险比（HR）和 95%置信区间（CI）。
与非 AUD 患者相比，调整患者社会人口统计学、并存合并症和医院特征后，AUD 患者发生肠系膜缺血的风险显著增加（HR=2.25；95%CI 1.92-2.64）。此外，在调整协变量后，酒精滥用/依赖（HR=2.29；95%CI 1.94-2.71）和酒精性精神病（HR=2.17；95%CI 1.72-2.73）患者发生肠系膜缺血的风险分别是无 AUD 对照患者的 2.29 倍和 2.17 倍。
本研究证实，不同 AUD 诊断类别的患者肠系膜缺血的风险显著增加，尤其是酒精滥用/依赖患者。
