弥漫性低级别胶质瘤相关癫痫
Diffuse Low-Grade Glioma-Related Epilepsy.
作者信息
Pallud Johan, McKhann Guy M
机构信息
Department of Neurosurgery, Sainte-Anne Hospital, 1 rue Cabanis, Paris Cedex 14 75674, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France; French Glioma Study Group, Réseau d'Etude des Gliomes, REG, Groland, France; Inserm, U894, Centre Psychiatrie et Neurosciences, Paris, France.
Department of Neurological Surgery, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
出版信息
Neurosurg Clin N Am. 2019 Jan;30(1):43-54. doi: 10.1016/j.nec.2018.09.001. Epub 2018 Nov 1.
The World Health Organization classifies diffuse low-grade gliomas (DLGGs) are highly epileptogenic primary brain tumors; epileptic seizures occur in more than 90% of cases. Epileptic seizures and drug resistance progress during the course of DLGGs. The glioma-related epileptogenic mechanisms are multifactorial; epileptogenic foci lie within the infiltrated peritumoral neocortex. A short seizure duration before surgery and a large extent of resection are the main predictors of postoperative seizure control in DLGGs. A supratotal resection of a DLGG can improve postoperative seizure control. Epileptic seizure at diagnosis positively affects DLGGs malignant transformation and overall survival.
世界卫生组织将弥漫性低级别胶质瘤（DLGGs）归类为高度致痫性原发性脑肿瘤；超过90%的病例会发生癫痫发作。在DLGGs病程中，癫痫发作和耐药性会进展。胶质瘤相关的致痫机制是多因素的；致痫灶位于肿瘤周围浸润的新皮层内。术前发作持续时间短和切除范围大是DLGGs术后癫痫控制的主要预测因素。DLGGs的超全切除可改善术后癫痫控制。诊断时的癫痫发作对DLGGs的恶性转化和总生存期有积极影响。
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