Jabs D A, Prendergast R A
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Invest Ophthalmol Vis Sci. 1988 Sep;29(9):1437-43.
Lacrimal gland inflammation develops in several strains of autoimmune mice, including MRL/Mp-lpr/lpr (MRL/lpr), MRL/Mp-+/+ (MRL/+), and NZBxNZW F1 hybrids (NZB/W). These mice all develop an autoimmune disease characterized by glomerulonephritis and autoantibody formation, but each strain has unique clinical features and immunologic abnormalities. Previous studies have suggested that the intrinsic immunologic defect in MRL/lpr mice may be at the level of T cells, while in NZB/W mice it appears to be B cell-mediated. Immunohistologic analysis of the lacrimal gland lesions was performed on all three strains. Although T cells predominated (MRL/lpr 85%, MLR/+ 78%, and NZB/W 57%), differences in the immunohistologic profiles did exist. NZB/W mice had a significantly higher percentage of B cells (33% vs. 10% for MRL/lpr and 13% for MRL/+) and a correspondingly lower percentage of T cells. MRL/lpr mice differed from MRL/+ mice in that they exhibited a significantly higher percentage of helper T cells (63% vs. 49%) and a lower percentage of suppressor/cytotoxic T cells (14% vs. 30%). Class II antigen expression could be detected on the mononuclear cells at inflammatory sites within the lacrimal glands of all three strains, suggesting T cell activation and an active autoimmune immunologic event occurring in the lacrimal gland.
泪腺炎症在几种自身免疫性小鼠品系中会发生，包括MRL/Mp-lpr/lpr（MRL/lpr）、MRL/Mp-+/+（MRL/+）和NZBxNZW F1杂交小鼠（NZB/W）。这些小鼠都会患上一种以肾小球肾炎和自身抗体形成为特征的自身免疫性疾病，但每个品系都有独特的临床特征和免疫异常。先前的研究表明，MRL/lpr小鼠的内在免疫缺陷可能在T细胞水平，而在NZB/W小鼠中，似乎是B细胞介导的。对所有这三个品系的泪腺病变进行了免疫组织学分析。尽管T细胞占主导（MRL/lpr为85%，MLR/+为78%，NZB/W为57%），但免疫组织学特征确实存在差异。NZB/W小鼠的B细胞百分比显著更高（33%，而MRL/lpr为10%，MRL/+为13%），相应地T细胞百分比更低。MRL/lpr小鼠与MRL/+小鼠的不同之处在于，它们表现出显著更高百分比的辅助性T细胞（63%对49%）和更低百分比的抑制性/细胞毒性T细胞（14%对30%）。在所有三个品系的泪腺炎症部位的单核细胞上都能检测到II类抗原表达，这表明T细胞被激活，且泪腺中发生了活跃的自身免疫免疫事件。
