Department of Chemical & Biomolecular Engineering, Seoul National University of Science and Technology (Seoul Tech), Seoul, South Korea.
Convergence Institute of Biomedical Engineering & Biomaterials, Seoul National University of Science and Technology (Seoul Tech), Seoul, South Korea.
Adv Exp Med Biol. 2018;1064:377-399. doi: 10.1007/978-981-13-0445-3_22.
Biomimetic medical materials are the biomaterials which mimic the important characteristic features of natural material/tissue structures or architectures and are mainly used in biomedical field for their applications in tissue regeneration, medical devices, biosensors and drug delivery. It is one of the leading research topics which have the ability to replace the existing biomaterials and medical devices and to development new biomaterials. The innovation and development in this research area are growing quickly because of the state-of-the-art techniques like nanobiotechnology, biosensors, tissue engineering and regenerative medicine, and 3D (bio)printing. These techniques can mimic the biomacromolecules, peptide sequences, morphology, chemical and physical structures more precisely than other currently available methods. The importance of hydrogels and its composites as examples among many other biomaterials are increasing vastly because of their recent advancements in its biological, chemical and physical cues which are biomimetic to native tissues. Furthermore, an enhancement in the 3D bioprinting technology where live cells are printed along with biomaterials demonstrates the capabilities of this technology to innovate novel tissue engineering products in micro- to macro-technology. The recent trends of development and intellectual properties related to biomimetic medical materials along with their perspectives and area of scope are discussed by focusing on 3D bioprinting in this chapter.
仿生医学材料是模仿天然材料/组织结构或架构的重要特征的生物材料，主要用于生物医学领域，用于组织再生、医疗器械、生物传感器和药物输送。它是最具前景的研究课题之一，有能力替代现有的生物材料和医疗器械，并开发新的生物材料。由于纳米生物技术、生物传感器、组织工程和再生医学以及 3D（生物）打印等先进技术的发展，该研究领域的创新和发展迅速。这些技术可以比其他现有方法更精确地模拟生物大分子、肽序列、形态、化学和物理结构。水凝胶及其复合材料的重要性正在大幅增加，因为它们在生物、化学和物理线索方面的最新进展类似于天然组织。此外，随着活细胞与生物材料一起打印的 3D 生物打印技术的提高，证明了该技术在微到宏观技术领域创新新型组织工程产品的能力。本章通过聚焦 3D 生物打印，讨论了仿生医学材料的最新发展趋势和相关知识产权及其观点和范围。
