Lykkegaard Nielsen M C, Vagn Nielsen O, Moesgaard F
Department of Surgical Gastroenterology, Rigshospitalet, University of Copenhagen, Denmark.
J Clin Gastroenterol. 1988 Aug;10(4):377-9. doi: 10.1097/00004836-198808000-00006.
A randomized trial with a blind observer compared the efficacy of an emulsion containing micronized sucralfate (1 g four times daily) and ranitidine (150 mg twice daily) in the short-term healing of peptic ulcer. Patients with a minimum ulcer size of 5 mm located in the duodenal bulb, the pyloric canal, or in the prepyloric area within a distance of 2 cm from the pylorus were included. A total of 97 patients were randomized and 85 completed the trial. The endoscopically proven healing rate at 2 weeks of 41% for both sucralfate and ranitidine improved to 76% for sucralfate and 73% for ranitidine at 4 weeks and to 95% and 96%, respectively, at 12 weeks. The difference between the two treatment groups was not statistically significant, and the 95% confidence interval for the difference in ulcer healing efficacy of sucralfate emulsion compared with ranitidine was -0.15 to +0.21 at 4 weeks and -0.10 to +0.08 at 12 weeks.
一项由盲法观察者参与的随机试验比较了含有微粉化硫糖铝（每日4次，每次1克）和雷尼替丁（每日2次，每次150毫克）的乳剂在消化性溃疡短期愈合中的疗效。纳入的患者溃疡最小尺寸为5毫米，位于十二指肠球部、幽门管或距幽门2厘米范围内的幽门前区域。共有97名患者被随机分组，85名完成了试验。硫糖铝和雷尼替丁在2周时经内镜证实的愈合率均为41%，4周时硫糖铝提高到76%，雷尼替丁提高到73%，12周时分别提高到95%和96%。两个治疗组之间的差异无统计学意义，硫糖铝乳剂与雷尼替丁相比，溃疡愈合疗效差异的95%置信区间在4周时为-0.15至+0.21，在12周时为-0.10至+0.08。
