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犰狳在麻风分枝杆菌实验性感染期间对酚糖脂-I的IgG和IgM抗体反应。

Armadillo IgG and IgM antibody responses to phenolic glycolipid-I during experimental infection with M. leprae.

作者信息

Vadiee A R, Shannon E J, Gillis T P, Mshana R N, Hastings R C

机构信息

Laboratory Research Branch, GWL Hansen's Disease Center, Carville, Louisiana 70721.

出版信息

Int J Lepr Other Mycobact Dis. 1988 Sep;56(3):422-7.

PMID:3047283
Abstract

The kinetics of antibody responses of Mycobacterium leprae-infected armadillos to phenolic glycolipid-I (PGL-I) were studied by means of ELISA. The levels of both IgG and IgM antibodies to PGL-I increased with time. Some animals were less susceptible to disseminations of M. leprae infection and lived longer than others. These animals had high absorbance values (greater than 0.7) for IgG anti-PGL-I compared to more susceptible armadillos that had lower absorbance values for IgG anti-PGL-I.

摘要

采用酶联免疫吸附测定法(ELISA)研究了感染麻风分枝杆菌的犰狳针对酚糖脂-I(PGL-I)的抗体反应动力学。针对PGL-I的IgG和IgM抗体水平均随时间升高。一些动物对麻风分枝杆菌感染的播散较不敏感,存活时间比其他动物更长。与对IgG抗PGL-I吸收值较低的更易感犰狳相比,这些动物的IgG抗PGL-I吸收值较高(大于0.7)。

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