Gogoleva V S, Atretkhany K-S N, Drutskaya M S, Mufazalov I A, Kruglov A A, Nedospasov S A
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
Lomonosov Moscow State University, Biological Faculty, Moscow, 119234, Russia.
Biochemistry (Mosc). 2018 Sep;83(9):1089-1103. doi: 10.1134/S0006297918090110.
Cytokines play a pivotal role in maintaining homeostasis of the immune system and in regulation of the immune response. Cytokine dysregulation is often associated with development of various pathological conditions, including autoimmunity. Recent studies have provided insights into the cytokine signaling pathways that are involved not only in pathogenesis of autoimmune neuroinflammatory disorders, such as multiple sclerosis, but also in neurodegenerative states, for example, Alzheimer's disease. Understanding the exact molecular mechanisms of disease pathogenesis and evaluation of relevant experimental animal models are necessary for development of effective therapeutic approaches.
细胞因子在维持免疫系统的稳态以及调节免疫反应中起着关键作用。细胞因子失调常与包括自身免疫在内的各种病理状况的发展相关。最近的研究深入揭示了细胞因子信号通路，这些通路不仅参与自身免疫性神经炎症性疾病（如多发性硬化症）的发病机制，还参与神经退行性疾病（如阿尔茨海默病）的发病机制。了解疾病发病的确切分子机制并评估相关实验动物模型对于开发有效的治疗方法是必要的。
