Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.
Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.
Trends Biochem Sci. 2019 Feb;44(2):153-166. doi: 10.1016/j.tibs.2018.10.011. Epub 2018 Nov 22.
The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.
乳酸在人类肿瘤中的存在长期以来一直被忽视，仅限于糖酵解产生的废物产物和恶性肿瘤的生物标志物的作用。最近，乳酸被重新发现为信号分子，在肿瘤微环境中调节代谢途径、免疫反应和细胞间通讯方面发挥着重要作用。本文综述了最近关于乳酸在塑造肿瘤和肿瘤相关细胞行为和表型方面的功能作用的发现，并描述了针对肿瘤中乳酸转运和代谢的潜在临床方法。
