Yang H C, Kuzur M
Br J Haematol. 1977 Nov;37(3):429-33. doi: 10.1111/j.1365-2141.1977.tb01014.x.
Nine haemophilia A patients with an inhibitor to factor VIII procoagulant and eight without an inhibitor were studied for the presence of an inhibitor to von Willebrand factor (vWf) in a quantitative ristocetin-induced platelet aggregation system. The mean vWf, factor VIII related antigen (FVIII Ag) and vWf:FVIII Ag ratio were not significantly different in the two groups (P greater than 0.6). The inhibitor plasmas did not reduce the wWf level in normal plasma after a 2 h incubation. The factor VIII inhibitor is highly specific for the procoagulant function of the factor VIII complex.
在定量的瑞斯托霉素诱导的血小板聚集系统中，对9例有抗凝血因子Ⅷ抑制剂的甲型血友病患者和8例无抑制剂的患者进行了血管性血友病因子（vWf）抑制剂检测。两组患者的平均vWf、因子Ⅷ相关抗原（FVIII Ag）和vWf:FVIII Ag比值无显著差异（P>0.6）。抑制剂血浆在孵育2小时后未降低正常血浆中的vWf水平。凝血因子Ⅷ抑制剂对凝血因子Ⅷ复合物的促凝血功能具有高度特异性。
