凝血因子VIII抑制剂的促凝特异性

Procoagulant specificity of factor VIII inhibitor.

作者信息

Yang H C, Kuzur M

出版信息

Br J Haematol. 1977 Nov;37(3):429-33. doi: 10.1111/j.1365-2141.1977.tb01014.x.

DOI:10.1111/j.1365-2141.1977.tb01014.x

Abstract

Nine haemophilia A patients with an inhibitor to factor VIII procoagulant and eight without an inhibitor were studied for the presence of an inhibitor to von Willebrand factor (vWf) in a quantitative ristocetin-induced platelet aggregation system. The mean vWf, factor VIII related antigen (FVIII Ag) and vWf:FVIII Ag ratio were not significantly different in the two groups (P greater than 0.6). The inhibitor plasmas did not reduce the wWf level in normal plasma after a 2 h incubation. The factor VIII inhibitor is highly specific for the procoagulant function of the factor VIII complex.

摘要

在定量的瑞斯托霉素诱导的血小板聚集系统中，对9例有抗凝血因子Ⅷ抑制剂的甲型血友病患者和8例无抑制剂的患者进行了血管性血友病因子（vWf）抑制剂检测。两组患者的平均vWf、因子Ⅷ相关抗原（FVIII Ag）和vWf:FVIII Ag比值无显著差异（P>0.6）。抑制剂血浆在孵育2小时后未降低正常血浆中的vWf水平。凝血因子Ⅷ抑制剂对凝血因子Ⅷ复合物的促凝血功能具有高度特异性。

相似文献

1

Procoagulant specificity of factor VIII inhibitor.凝血因子VIII抑制剂的促凝特异性

Br J Haematol. 1977 Nov;37(3):429-33. doi: 10.1111/j.1365-2141.1977.tb01014.x.

2

IgA inhibitor to factor VIII/von Willebrand factor.

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3

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4

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The combined use of monoclonal antibody-based enzyme-linked immunosorbent assays (ELISA) for factor VIII antigen (VIII:Ag) and von Willebrand factor antigen (vWF:Ag) for the detection of carriers of haemophilia A.基于单克隆抗体的酶联免疫吸附测定法（ELISA）联合检测因子VIII抗原（VIII:Ag）和血管性血友病因子抗原（vWF:Ag）以检测甲型血友病携带者。

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6

Autoantibody to factor VIII that has less reactivity to factor VIII/von Willebrand factor complex.对VIII因子具有自身抗体，该自身抗体对VIII因子/血管性血友病因子复合物的反应性较低。

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Immune tolerance induction with highly purified plasma-derived factor VIII containing von Willebrand factor in hemophilia A patients with high-responding inhibitors.在高反应性抑制物的甲型血友病患者中，使用含有血管性血友病因子的高纯度血浆源性凝血因子VIII诱导免疫耐受。

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8

Influence of von Willebrand factor on the reactivity of human factor VIII inhibitors with factor VIII.血管性血友病因子对人凝血因子VIII抑制剂与凝血因子VIII反应性的影响。

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9

Acquired von Willebrand syndrome due to an inhibitor specific for von Willebrand factor antigens.

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10

Pseudo-von Willebrand's disease. An intrinsic platelet defect with aggregation by unmodified human factor VIII/von Willebrand factor and enhanced adsorption of its high-molecular-weight multimers.假性血管性血友病。一种血小板内在缺陷，其表现为未修饰的人凝血因子VIII/血管性血友病因子可引起血小板聚集，且其高分子量多聚体的吸附增强。

N Engl J Med. 1982 Feb 11;306(6):326-33. doi: 10.1056/NEJM198202113060603.

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