Nygren A, Bulow G, Sundblad L, Thunberg E, Wiechel K L
Department of Medicine II, Södersjukhuset, Stockholm, Sweden.
Metabolism. 1988 Sep;37(9):810-4. doi: 10.1016/0026-0495(88)90112-6.
The effect of glipizide on hepatic uptake of insulin was studied in five patients with liver cirrhosis and five patients with varying diseases in the biliary system and pancreas. All patients had portal catheters for diagnostic purposes. The hepatic uptake of insulin was estimated from the clearance rate for insulin obtained after a constant rate infusion into a peripheral vein and the portal vein. Each patient was examined on two consecutive mornings, the second investigation carried out one hour after oral glipizide administration. The fractional hepatic uptake was significantly lower in cirrhotic patients (17% +/- 6%) than in the other patients (52% +/- 7%; P less than .01). After glipizide, an increase in the estimated uptake of insulin occurred in cirrhotic patients (from 17% +/- 6% to 39% +/- 6%; P less than .01), whereas an insignificant decrease was observed in the other patients (from 52% +/- 7% to 43% +/- 11%).
在五名肝硬化患者以及五名患有不同胆道和胰腺疾病的患者中研究了格列吡嗪对肝脏摄取胰岛素的影响。所有患者均因诊断目的而留置门静脉导管。通过外周静脉和门静脉恒速输注胰岛素后获得的胰岛素清除率来估算肝脏对胰岛素的摄取。每位患者在连续两个早晨接受检查，第二次检查在口服格列吡嗪一小时后进行。肝硬化患者的肝脏摄取分数（17%±6%）显著低于其他患者（52%±7%；P＜0.01）。服用格列吡嗪后，肝硬化患者估算的胰岛素摄取量增加（从17%±6%增至39%±6%；P＜0.01），而其他患者则出现不显著的下降（从52%±7%降至43%±11%）。
