Hogan Elizabeth, Almira-Suarez Isabel, Li Siyuan, Collins Sean P, Jean Walter C
Department of Neurological Surgery, George Washington University, Washington, D.C., USA.
Department of Pathology, Children's National Medical Center, Washington, D.C., USA.
World Neurosurg. 2019 Feb;122:464-468. doi: 10.1016/j.wneu.2018.11.111. Epub 2018 Nov 24.
Prostate cancer is the most common cancer among American men, with an incidence of approximately 233,000 cases per year. Intracranial metastases are rare and, specifically, metastasis to the pineal gland has only been reported in 2 postmortem cases in the literature.
We present the first documented case of confirmed prostate cancer metastasis to the pineal gland in a living patient. The patient underwent an endoscopic third ventriculostomy and pineal lesion biopsy with complete resolution of his hydrocephalus and presenting symptoms. His biopsy results confirmed the prostate origin of the metastasis, and he subsequently underwent stereotactic radiosurgery for treatment of this lesion.
This is the first report of the clinical management of metastatic prostate cancer to the pineal region and description of the clinical outcome. Although prostate cancer is the most common cancer in American men, metastasis to the pineal has only been reported twice from autopsy examinations. Overall, pineal tumors in the geriatric population are exceedingly rare and the age and comorbidities in this patient made management quite unique.
前列腺癌是美国男性中最常见的癌症，每年发病率约为233,000例。颅内转移罕见，具体而言，转移至松果体的情况在文献中仅报道过2例尸检病例。
我们报告了首例有记录的在世患者确诊前列腺癌转移至松果体的病例。该患者接受了内镜下第三脑室造瘘术和松果体病变活检，脑积水及相关症状完全缓解。活检结果证实转移灶起源于前列腺，随后他接受了立体定向放射外科治疗该病变。
这是首例关于前列腺癌转移至松果体区域的临床管理及临床结果描述的报告。尽管前列腺癌是美国男性中最常见的癌症，但从尸检中转移至松果体的情况仅报道过两次。总体而言，老年人群中的松果体肿瘤极为罕见，该患者的年龄和合并症使得治疗颇具特殊性。
