Gold P W, Pigott T A, Kling M A, Kalogeras K, Chrousos G P
Section on Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, Maryland.
Psychiatr Clin North Am. 1988 Jun;11(2):327-34.
We have presented several lines of circumstantial evidence suggesting a possible role for CRH in the panic disorder syndrome. Such a role has by no means been demonstrated and is indeed challenged by several lines of contradictory data. Critical evaluation of this hypothesis must await further basic research on the role of hypothalamic and extrahypothalamic CRH in stress-mediated phenomena and on their interrelationships. Moreover, additional clinical research will be required to further delineate the landscape of hypothalamic-pituitary-adrenal function in patients with panic disorder both during acute panic episodes and intercurrently.
我们已经提出了几条间接证据，表明促肾上腺皮质激素释放激素（CRH）在惊恐障碍综合征中可能发挥作用。然而，这一作用尚未得到证实，实际上还受到了几条相互矛盾数据的质疑。对这一假说的批判性评估必须等待关于下丘脑和下丘脑外CRH在应激介导现象中的作用及其相互关系的进一步基础研究。此外，还需要更多的临床研究来进一步描绘惊恐障碍患者在急性惊恐发作期间及发作间期下丘脑-垂体-肾上腺功能的全貌。
