Jun Jae Chang, Yoon Hyuk, Choi Yoon Jin, Shin Cheol Min, Park Young Soo, Kim Nayoung, Lee Dong Ho, Kim Joo Sung
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Intest Res. 2019 Apr;17(2):210-217. doi: 10.5217/ir.2018.00081. Epub 2018 Nov 27.
BACKGROUND/AIMS: The exact relationship between vitamin D deficiency and inflammatory bowel disease (IBD) remains unclear. We evaluated the effect of vitamin D3 administration on inflammatory responses and disease severity in patients with IBD.
We investigated the serum 25-hydroxyvitamin D3 [25-(OH)D] and C-reactive protein (CRP) levels and the partial Mayo score (PMS) in patients with IBD. Vitamin D3 was administered in patients with either vitamin D deficiency or insufficiency and CRP serum vitamin D levels and PMS were re-examined at 6 months of administration.
In 88 patients with Crohn's disease (CD), a negative correlation was found between serum vitamin D and CRP. In 178 patients with ulcerative colitis (UC), serum vitamin D showed no association with CRP or PMS. Serum vitamin D increased from 11.08±3.63 to 22.69±6.11 ng/mL in 29 patients with CD and from 11.45±4.10 to 24.20±6.61 ng/mL in 41 patients with UC who received vitamin D3 treatment (P<0.001 and P<0.001, respectively). In patients with CD, median ΔCRP was -0.24 in the normalized vitamin D group and -0.11 in the non-normalized group (P=0.308). In patients with UC, median ΔCRP was -0.01 in the normalized vitamin D group and 0.06 in the non-normalized group (P=0.359).
Although a negative correlation was found between serum vitamin D and CRP levels in patients with CD, administration of vitamin D did not improve the CRP level in patients with CD. In patients with UC, serum vitamin D level was unrelated to CRP or PMS.
背景/目的：维生素D缺乏与炎症性肠病（IBD）的确切关系仍不清楚。我们评估了给予维生素D3对IBD患者炎症反应和疾病严重程度的影响。
我们调查了IBD患者的血清25-羟基维生素D3 [25-(OH)D]、C反应蛋白（CRP）水平和部分梅奥评分（PMS）。对维生素D缺乏或不足的患者给予维生素D3，并在给药6个月时重新检查CRP、血清维生素D水平和PMS。
在88例克罗恩病（CD）患者中，血清维生素D与CRP之间存在负相关。在178例溃疡性结肠炎（UC）患者中，血清维生素D与CRP或PMS无关联。接受维生素D3治疗的29例CD患者血清维生素D从11.08±3.63 ng/mL升至22.69±6.11 ng/mL，41例UC患者从11.45±4.10 ng/mL升至24.20±6.61 ng/mL（分别为P<0.001和P<0.001）。在CD患者中，维生素D正常化组的中位ΔCRP为-0.24，未正常化组为-0.11（P=0.308）。在UC患者中，维生素D正常化组的中位ΔCRP为-0.01，未正常化组为0.06（P=0.359）。
虽然在CD患者中血清维生素D与CRP水平之间存在负相关，但给予维生素D并未改善CD患者的CRP水平。在UC患者中，血清维生素D水平与CRP或PMS无关。
