Yang Yu-Lan, Wu Ben-Qing, Su Jin-Zhen, Yang Lin, Zhong Gui-Chao, Liu Lan
Department of Neonatology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Nov;20(11):897-903. doi: 10.7499/j.issn.1008-8830.2018.11.004.
To systematically evaluate the clinical efficacy of nasal high-frequency ventilation (nHFV) in the treatment of neonatal respiratory distress syndrome (NRDS).
A literature search was performed in PubMed, Cochrane Library, EMBase (Ovid), Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Wanfang Data, and Weipu Data to collect the randomized controlled trials (RCTs) that compared the clinical efficacy of nHFV and nasal continuous positive airway pressure (nCPAP) in the treatment of NRDS. A Meta analysis was performed on the included RCTs using Rev Man 5.3 software after data extraction and quality evaluation by Cochrane 5.1.0.
A total of 4 RCTs involving 218 patients were included. The Meta analysis showed that compared with the nCPAP group, the nHFV group had a significantly better treatment outcome (RR=1.73, 95%CI: 1.39-2.15, P<0.00001). There were no significant differences in the incidence rates of intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, necrotizing enterocolitis, pneumothorax and retinopathy of prematurity.
Compared with nCPAP, nHFV has better clinical efficacy in the treatment of NRDS, without increasing the risk of related complications.
系统评价经鼻高频通气（nHFV）治疗新生儿呼吸窘迫综合征（NRDS）的临床疗效。
通过检索PubMed、Cochrane图书馆、EMBase（Ovid）、中国生物医学文献数据库、中国期刊全文数据库、万方数据和维普数据，收集比较nHFV与经鼻持续气道正压通气（nCPAP）治疗NRDS临床疗效的随机对照试验（RCT）。采用Cochrane 5.1.0进行数据提取和质量评价后，使用Rev Man 5.3软件对纳入的RCT进行Meta分析。
共纳入4项RCT，涉及218例患者。Meta分析显示，与nCPAP组相比，nHFV组治疗效果显著更好（RR=1.73，95%CI：1.39-2.15，P<0.00001）。脑室内出血、脑室周围白质软化、支气管肺发育不良、坏死性小肠结肠炎、气胸和早产儿视网膜病变的发生率无显著差异。
与nCPAP相比，nHFV治疗NRDS临床疗效更好，且不增加相关并发症风险。
