Wodajo Felasfa M, Jakus Adam E
Virginia Cancer Specialists, 8503 Arlington Boulevard, Suite 400, Fairfax, VA 22031, USA; Orthopedic Surgery, VCU School of Medicine, Inova Campus, Fairfax, VA 22042, USA; Orthopedic Surgery, Georgetown University Hospital, Washington, DC 20007, USA.
Dimension Inx LLC, 303 East Superior Street, 11th Floor, Chicago, IL 60611, USA.
Orthop Clin North Am. 2019 Jan;50(1):21-33. doi: 10.1016/j.ocl.2018.08.013.
In part 1 of this article, the authors explore nanoscale modifications of the surfaces of biomaterials, which offer an exciting potential venue for the prevention of bacterial adhesion and growth. Despite advances in the design and manufacture of implants, infection remains an important and often devastating mode of failure. In part 2, additive technologies for tissue engineering, live cell printing (bioprinting), and tissue fabrication are briefly introduced. The similarities and differences between bioprinting and non-bio 3D-printing approaches and requirements are discussed, along with terminological definitions, current processes, requirements, and biomaterial and cell-type selection and sourcing.
在本文的第一部分，作者探讨了生物材料表面的纳米级修饰，这为预防细菌黏附和生长提供了一个令人兴奋的潜在途径。尽管植入物的设计和制造取得了进展，但感染仍然是一种重要且常常具有毁灭性的失效模式。在第二部分中，简要介绍了用于组织工程的添加剂技术、活细胞打印（生物打印）和组织制造。讨论了生物打印与非生物3D打印方法和要求之间的异同，以及术语定义、当前工艺、要求、生物材料和细胞类型的选择与来源。
