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Increased risk of heparin induced thrombocytopenia and thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation.

作者信息

Castelli Roberto, Gallipoli Paolo, Schiavon Riccardo, Teatini Thomas, Deliliers Giorgio Lambertenghi, Bergamaschini Luigi

机构信息

Department of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, UK.

出版信息

J Thromb Thrombolysis. 2019 Jan;47(1):155-156. doi: 10.1007/s11239-018-1773-4.

DOI:10.1007/s11239-018-1773-4
PMID:30478722
Abstract
摘要

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Increased risk of heparin induced thrombocytopenia and thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation.携带纯合JAK2 V617F突变的原发性血小板增多症患者发生肝素诱导的血小板减少症和血栓形成的风险增加。
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2
High prevalence of heparin induced thrombocytopenia with thrombosis among patients with essential thrombocytemia carrying V617F mutation.携带 V617F 突变的原发性血小板增多症患者肝素诱导的血小板减少症伴血栓形成的高发率。
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1
High prevalence of heparin induced thrombocytopenia with thrombosis among patients with essential thrombocytemia carrying V617F mutation.携带 V617F 突变的原发性血小板增多症患者肝素诱导的血小板减少症伴血栓形成的高发率。
J Thromb Thrombolysis. 2018 Jan;45(1):106-113. doi: 10.1007/s11239-017-1566-1.
2
Thrombosis and hemostatic abnormalities in hematological malignancies.血液系统恶性肿瘤中的血栓形成与止血异常
Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):441-50. doi: 10.1016/j.clml.2014.05.003. Epub 2014 Jun 11.
3
JAK2 p.V617F detection and allele burden measurement in peripheral blood and bone marrow aspirates in patients with myeloproliferative neoplasms.
What cardiologists should know about essential thrombocythemia and acute myocardial infarction: report of two cases and advanced heart failure therapies considerations.
心脏病专家应了解的原发性血小板增多症与急性心肌梗死：两例报告及晚期心力衰竭治疗考量
Int Med Case Rep J. 2019 Aug 8;12:253-259. doi: 10.2147/IMCRJ.S217568. eCollection 2019.
4
Genetic factors affecting thrombosis in patients with essential thrombocythemia by heparin treatment.肝素治疗对原发性血小板增多症患者血栓形成的遗传影响因素。
J Thromb Thrombolysis. 2019 Oct;48(3):514-515. doi: 10.1007/s11239-019-01886-x.
JAK2 p.V617F 检测及等位基因负荷在骨髓和外周血中的检测在骨髓增殖性肿瘤患者中的应用。
Blood. 2013 Nov 28;122(23):3784-6. doi: 10.1182/blood-2013-07-515676. Epub 2013 Sep 25.
4
Increased risk of recurrent thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation.携带 JAK2 V617F 突变纯合子的原发性血小板增多症患者复发性血栓形成风险增加。
Ann Hematol. 2010 Feb;89(2):141-6. doi: 10.1007/s00277-009-0788-5. Epub 2009 Jul 7.
5
Thromboembolic complications in malignant haematological disorders.恶性血液病中的血栓栓塞并发症。
Curr Vasc Pharmacol. 2010 Jul;8(4):482-94. doi: 10.2174/157016110791330799.
6
Influence of the JAK2 V617F mutation and inherited thrombophilia on the thrombotic risk among patients with essential thrombocythemia.JAK2 V617F突变和遗传性血栓形成倾向对原发性血小板增多症患者血栓形成风险的影响。
Haematologica. 2009 May;94(5):733-7. doi: 10.3324/haematol.13869. Epub 2009 Mar 31.
7
Influence of JAK2V617F allele burden on phenotype in essential thrombocythemia.JAK2V617F等位基因负荷对原发性血小板增多症表型的影响。
Haematologica. 2008 Jan;93(1):41-8. doi: 10.3324/haematol.11653.
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Blood. 2007 Aug 1;110(3):840-6. doi: 10.1182/blood-2006-12-064287. Epub 2007 Mar 22.