Kmyta V V, Garbuzova V Y, Prystupa E N, Prystupa L N
Tsitol Genet. 2016 May-Jun;50(3):36-41.
The objective of this investigation was to analyze possible association between BclI polymorphism of glucocorticoid receptor gene and obesity in patients with bronchial asthma (BA). The study involved 188 patients with bronchial asthma and 95 apparently healthy adult individuals. Generally accepted assessments and examinations for BA diagnosis, and anthropometric, molecular-genetic and statistic methods of investigation were used in the research. It was found out that the patients with BA demonstrated higher body mass index (BMI) and higher ratio of fat centralization much more often, than the control group. Genotypes distribution for BclI polymorphism in patients with BA showed a statistically significant difference between patients with different BMI unlike the control group. Comparison of genotype frequency for BclI polymorphism in glucocorticoid receptor gene in individuals with different ratio of fat centralization in the control group and in the patients with BA separately showed statistically significant differences in the distribution of gene allelic variations only among the patients with BA. It was demonstrated that G/G genotype in the patients with visceral obesity was associated with BA.
本研究的目的是分析支气管哮喘（BA）患者糖皮质激素受体基因BclI多态性与肥胖之间的可能关联。该研究纳入了188例支气管哮喘患者和95例表面健康的成年人。研究采用了公认的BA诊断评估和检查方法，以及人体测量、分子遗传学和统计学研究方法。结果发现，与对照组相比，BA患者更常表现出较高的体重指数（BMI）和较高的脂肪集中比例。BA患者中BclI多态性的基因型分布显示，不同BMI的患者之间存在统计学显著差异，这与对照组不同。分别比较对照组和BA患者中不同脂肪集中比例个体的糖皮质激素受体基因BclI多态性的基因型频率，结果显示仅在BA患者中基因等位变异的分布存在统计学显著差异。结果表明，内脏肥胖患者的G/G基因型与BA有关。
