对一名患有严重联合免疫缺陷（SCID）的三岁患者在“悉生生物保护”条件下的T和B淋巴细胞进行的纵向研究。
A longitudinal study of T and B lymphocytes from a three-year-old patient with severe combined immunodeficiency (SCID) in 'gnotobiotic protection'.
作者信息
Mukhopadhyay N, Richie E, Mackler B F, Montgomery J R, Wilson R, Fernbach D J, South M A
出版信息
Exp Hematol. 1978 Feb;6(2):129-34.
Fluctuations in the percentages and absolute numbers of T and B lymphocytes were observed in the peripheral blood of a patient with severe combined immunodeficiency maintained in a gnotobiotic environment. Up to 24 months of age, 72-86% of the lymphocytes had surface membrane immunoglobulin (SMIg), 37-47% bore a receptor for C3(EAC-RFC), and 3-12.5% formed spontaneous rosettes with sheep erythrocytes (E-RFC). These values persisted until 30 months, after which shifts in the percentages and absolute numbers of T and B cells were observed. A significant decrease in the proportion of SMIg-bearing cells to 20-40% (169-405 mm3), and EAC-RFC to 10.5-39% (114-259 mm3), was accompanied by a general increase in the proportion of T cells to 19-60% (141-1026 mm3), representing a lymphoid subpopulation approach to normal levels.
在无菌环境中维持的严重联合免疫缺陷患者的外周血中，观察到T淋巴细胞和B淋巴细胞的百分比及绝对数量的波动。在24个月龄之前，72%至86%的淋巴细胞具有表面膜免疫球蛋白（SMIg），37%至47%带有C3受体（EAC-RFC），3%至12.5%与绵羊红细胞形成自发玫瑰花结（E-RFC）。这些数值一直持续到30个月，之后观察到T细胞和B细胞的百分比及绝对数量发生变化。带有SMIg的细胞比例显著下降至20%至40%（169至405/mm³），EAC-RFC下降至10.5%至39%（114至259/mm³），同时T细胞比例总体增加至19%至60%（141至1026/mm³），表明淋巴细胞亚群接近正常水平。
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