儿茶酚-O-甲基转移酶 Val158Met 多态性与慢性偏头痛女性的焦虑、抑郁和广泛压痛敏感性相关，但与发作性偏头痛无关。

Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine.

机构信息

Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.

Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.

出版信息

Pain Med. 2019 Jul 1;20(7):1409-1417. doi: 10.1093/pm/pny237.

DOI:10.1093/pm/pny237

PMID:30481348

Abstract

OBJECTIVES

To analyze the association between the rs4680 catechol-O-methyltransferase Val158Met polymorphism and to determine the association of this polymorphism with clinical, psychological, and pain sensitivity variables in women with episodic or chronic migraine.

METHODS

Fifty women with episodic migraine, 50 with chronic migraine, and 50 matched healthy women participated. After amplifying the Val158Met polymorphism by polymerase chain reaction, we assessed genotype frequencies and allele distributions. Participants were classified according to the Val158Met polymorphism genotype into Val/Val, Val/Met, or Met/Met. A headache diary was used for collecting migraine pain features. Disability was assessed with the Migraine Disability Assessment Scale, trait/state anxiety levels with the State-Trait Anxiety Inventory, and depression/anxiety with the Hospital Anxiety and Depression Scale. Pressure pain thresholds (PPTs) were bilaterally assessed over the temporalis, the upper trapezius, the second metacarpal, and the tibialis anterior.

RESULTS

The distribution of the rs4680 Val158Met genotype was not significantly different between women with and without migraine (P = 0.157). No differences in migraine features were found to be dependent on the Val158Met genotype. Women with the Met/Met genotype showed higher migraine-related disability than those with the Val/Val or Val/Met genotype in both migraine groups (P < 0.01). Women with chronic, but not episodic, migraine with the Met/Met genotype exhibited higher depressive and anxiety levels and lower PPTs than those with the Val/Val or Val/Met genotype.

CONCLUSIONS

The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype.

摘要

目的

分析儿茶酚氧位甲基转移酶（COMT） rs4680 第 158 位缬氨酸到蛋氨酸（Val158Met）多态性与女性发作性或慢性偏头痛之间的关联，并确定该多态性与偏头痛的临床、心理和疼痛敏感性变量之间的关联。

方法

共纳入 50 例发作性偏头痛患者、50 例慢性偏头痛患者和 50 例匹配的健康女性。通过聚合酶链反应扩增 Val158Met 多态性后，评估基因型频率和等位基因分布。根据 Val158Met 多态性基因型将患者分为 Val/Val、Val/Met 或 Met/Met 基因型。使用头痛日记记录偏头痛疼痛特征。使用偏头痛残疾评估量表（MIDAS）评估残疾程度，使用状态特质焦虑量表（STAI）评估特质/状态焦虑水平，使用医院焦虑抑郁量表（HADS）评估抑郁/焦虑程度。双侧评估颞肌、上斜方肌、第二掌骨和胫骨前肌的压痛阈值（PPT）。

结果

发作性和慢性偏头痛患者间 rs4680 Val158Met 基因型的分布无显著差异（P=0.157）。偏头痛特征也与 Val158Met 基因型无关。在两个偏头痛组中，携带 Met/Met 基因型的女性偏头痛相关残疾程度均高于 Val/Val 或 Val/Met 基因型的女性（P<0.01）。与 Val/Val 或 Val/Met 基因型的女性相比，患有慢性偏头痛但不患有发作性偏头痛的女性携带 Met/Met 基因型时表现出更高的抑郁和焦虑水平以及更低的 PPT（P<0.01）。