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韩国人类患者和零售肉类中产生志贺毒素的O91:H14分离株序列类型33的分子流行病学

Molecular epidemiology of sequence type 33 of Shiga toxin-producing O91:H14 isolates from human patients and retail meats in Korea.

作者信息

Lee Jun Bong, Kim Se-Kye, Wi Seon Mi, Cho Young-Jae, Hahn Tae-Wook, Yu Jae-Yon, Kim Sungsun, Hong Sahyun, Kim Jonghyun, Yoon Jang Won

机构信息

College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea.

Division of Bacterial Disease Research, Center for Infectious Diseases Research, Korea National Institute of Health, Centers for Disease Control and Prevention, Cheongju 28159, Korea.

出版信息

J Vet Sci. 2019 Jan 31;20(1):87-90. doi: 10.4142/jvs.2019.20.1.87.

Abstract

Sequence type (ST) 33 of Shiga toxin-producing (STEC) strain O91:H14 has been proposed as a potential domestic clone of STEC in Korea because of its high prevalence among human patients with mild diarrhea or asymptomatic carriers. Herein, the clonal diversity of 17 STEC O91:H14 isolates of ST33 during 2003 to 2014 was analyzed by pulsed-field gel electrophoresis, including 14 isolates from human patients and 3 from retail meats. Their virulence characteristics, acid resistance, and antimicrobial susceptibility were also determined. Our results showed that all isolates were clustered mainly into three different pulsotypes and were likely low pathogenic without antimicrobial resistance.

摘要

产志贺毒素大肠杆菌(STEC)O91:H14菌株的序列类型(ST)33,因其在轻度腹泻人类患者或无症状携带者中高流行率,而被认为是韩国STEC的一个潜在本土克隆株。在此,通过脉冲场凝胶电泳分析了2003年至2014年间17株ST33的STEC O91:H14分离株的克隆多样性,其中包括14株来自人类患者的分离株和3株来自零售肉类的分离株。还测定了它们的毒力特征、耐酸性和抗菌药敏性。我们的结果表明,所有分离株主要聚为三种不同的脉冲型,可能致病性较低且无抗菌耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404e/6351770/e4cd4ada1751/jvs-20-87-g001.jpg

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