同时使用两种快速诊断测试来诊断恰加斯病。
Simultaneous use of two rapid diagnostic tests for the diagnosis of Chagas disease.
作者信息
Mendicino Diego, Colussi Carlina, Moretti Edgardo
机构信息
1 Researcher, Centro de Investigaciones sobre Endemias Nacionales, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
2 Research associate, Instituto de Medicina y Biología Experimental de Cuyo, CCT-CONICET, Mendoza, Argentina.
出版信息
Trop Doct. 2019 Jan;49(1):23-26. doi: 10.1177/0049475518813792. Epub 2018 Nov 27.
The sensitivity of rapid diagnostic tests (RDT) for Chagas disease is not great enough for their single use. The aim of this paper was to evaluate the performance of two RDTs for Chagas disease, used simultaneously. Two different RDTs (A and B) were performed in 64 and 42 serum samples that were negative and positive, respectively, by conventional serological techniques. Validity and reliability of both tests were evaluated individually and simultaneously. Sensitivity was 90.5% and 97.6%, and specificity was 100% and 93.8%, for RDT A and B, respectively. The κ statistic was 0.96. When both RDTs were used simultaneously, sensitivity was 97.4%, specificity was 100% and the discordance percentage 6.6%. The combined use of two RDTs with serum samples is an acceptable application in healthcare centres.
用于恰加斯病的快速诊断检测（RDT）灵敏度不够高，无法单独使用。本文旨在评估同时使用两种用于恰加斯病的RDT的性能。分别用两种不同的RDT（A和B）对64份和42份血清样本进行检测，这些样本通过传统血清学技术检测分别为阴性和阳性。对两种检测的有效性和可靠性分别以及同时进行了评估。RDT A和B的灵敏度分别为90.5%和97.6%，特异性分别为100%和93.8%。κ统计量为0.96。当同时使用两种RDT时，灵敏度为97.4%，特异性为100%，不一致率为6.6%。在医疗中心，将两种RDT与血清样本联合使用是一种可接受的应用方式。
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