Henzen Christoph
1 Innere Medizin/Endokrinologie und Diabetologie, Luzerner Kantonsspital.
Praxis (Bern 1994). 2018 Nov;107(24):1309-1315. doi: 10.1024/1661-8157/a003132.
Paraneoplastic Endocrine Syndromes Abstract. Paraneoplastic endocrine syndromes are caused by ectopic hormone production by malignant tumor cells. Knowledge of paraneoplastic endocrine syndromes may allow a timely diagnosis of the underlying cancer at a treatable stage and, on the other hand, appropriate treatment of the endocrine manifestations reduces morbidity and mortality of the affected patients. The most common endocrine syndromes are paraneoplastic hypercalcaemia, caused by the secretion of PTHrP, and hyponatremia, caused by the inadequate secretion of ADH. Although there may be clinical symptoms like fatigue, nausea/vomiting and renal insufficiency for hypercalcaemia and gait disturbances and mental alterations for hyponatremia, the diagnosis must be confirmed by laboratory testing and prompt the search for associated tumors.
副肿瘤性内分泌综合征摘要。副肿瘤性内分泌综合征是由恶性肿瘤细胞异位产生激素所致。了解副肿瘤性内分泌综合征有助于在可治疗阶段及时诊断潜在癌症，另一方面，对内分泌表现进行适当治疗可降低受影响患者的发病率和死亡率。最常见的内分泌综合征是由甲状旁腺激素相关蛋白（PTHrP）分泌引起的副肿瘤性高钙血症，以及由抗利尿激素分泌不足引起的低钠血症。虽然高钙血症可能有疲劳、恶心/呕吐和肾功能不全等临床症状，低钠血症有步态障碍和精神改变等症状，但诊断必须通过实验室检查来确认，并促使寻找相关肿瘤。
