Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, Russia, 119021.
J Antibiot (Tokyo). 2019 Feb;72(2):122-124. doi: 10.1038/s41429-018-0122-3. Epub 2018 Nov 28.
A series of 3,4-bis(arylthio)maleimides were synthesized and their antimicrobial activity was evaluated against Gram-positive and Gram-negative bacteria, including multidrug resistant (MDR) strains and some fungi. Most compounds turned out to be highly active, activity being dependent on substituents on phenyl rings.
合成了一系列 3,4-双（芳基硫代）马来酰亚胺，并评估了它们对革兰氏阳性和革兰氏阴性细菌（包括多药耐药（MDR）菌株和一些真菌）的抗菌活性。大多数化合物表现出很高的活性，活性取决于苯环上的取代基。
