聚乙二醇天冬酰胺酶在1例肝脾γδ T细胞淋巴瘤中的应用及干细胞移植后长期缓解情况
Use of PEG-asparaginase in a case of Hepatosplenic γδ T-cell lymphoma with long-term remission after stem cell transplantation.
作者信息
Sun Kai, Sanchez Cesar Gentille, Pingali Sai Ravi, Iyer Swaminathan
机构信息
Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Department of Hematology, Houston Methodist Hospital, Houston, TX 77030, USA.
出版信息
Ecancermedicalscience. 2018 Sep 20;12:872. doi: 10.3332/ecancer.2018.872. eCollection 2018.
Abstract
Hepatosplenic γδ T-cell lymphoma (HSTCL) is a rare aggressive peripheral T-cell lymphoma. Prognosis is usually poor with a median survival between 8 and 16 months after traditional chemotherapy. Stem cell transplantation (SCT) is promising and with a more intense induction regimen, has yielded positive results. We report the use of pegylated-asparaginase (PEG-asparaginase) along with a conventional anthracycline-containing regimen in a 51-year-old male who was diagnosed with HSTCL, achieved a complete remission, and subsequently underwent peripheral blood SCT and remained in remission at the time of this case report.
摘要
肝脾γδ T细胞淋巴瘤（HSTCL）是一种罕见的侵袭性外周T细胞淋巴瘤。传统化疗后的预后通常较差，中位生存期在8至16个月之间。干细胞移植（SCT）前景良好，采用更强的诱导方案已取得了积极成果。我们报告了一名51岁男性患者，其被诊断为HSTCL，使用聚乙二醇化天冬酰胺酶（PEG-天冬酰胺酶）联合含蒽环类药物的传统方案治疗，实现了完全缓解，随后接受了外周血SCT，在本病例报告时仍处于缓解状态。
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