从尼日利亚奥贡莫索的猪身上分离出的甲型H5N1流感病毒/2014的静脉致病性。
Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria.
作者信息
Oladipo E Kolawole, Oloke J Kola, Adeniji J Adekunle
机构信息
Department of Microbiology, Virus Research Laboratory, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
Department of Pure and Applied Biology (Microbiology Unit), Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, Nigeria.
出版信息
Open Vet J. 2018;8(3):347-350. doi: 10.4314/ovj.v8i3.16. Epub 2018 Sep 30.
Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an outbreak among pig and have now aimed to assess its pathogenicity in an avian host and to categorize it as a low or high pathogenic strain. Intravenous pathogenicity index of the isolated virus was assayed using experimental infection of 6 weeks old pathogen-specific free chicken. The peak of clinical signs was on day three post-infection, and one death was observed on day eight. The intravenous pathogenicity index of this isolate was 0.08. This results classify this isolate as a low pathogenic avian influenza strain.
由于抗原转变/漂移以及新型潜在人类致病菌株的来源，了解禽流感病毒在家禽中的致病性是一项重要的科学和公共卫生挑战。我们之前从猪群疫情中分离出一株甲型流感病毒（H5N1/2014/奥贡莫索），现在旨在评估其在禽类宿主中的致病性，并将其归类为低致病性或高致病性菌株。使用6周龄特定病原体无特定病原体鸡进行实验性感染，测定分离病毒的静脉致病性指数。临床症状高峰出现在感染后第三天，第八天观察到一例死亡。该分离株的静脉致病性指数为0.08。这一结果将该分离株归类为低致病性禽流感毒株。
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