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Nucleoside and nucleobase transport in animal cells.

作者信息

Plagemann P G, Wohlhueter R M, Woffendin C

机构信息

Department of Microbiology, University of Minnesota, Minneapolis 55455.

出版信息

Biochim Biophys Acta. 1988 Oct 11;947(3):405-43. doi: 10.1016/0304-4157(88)90002-0.

DOI:10.1016/0304-4157(88)90002-0
PMID:3048401
Abstract
摘要

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Nucleoside and nucleobase transport in animal cells.动物细胞中的核苷和核碱基转运
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Species differences in sensitivity of nucleoside transport in erythrocytes and cultured cells to inhibition by nitrobenzylthioinosine, dipyridamole, dilazep and lidoflazine.
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Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep.平衡核苷转运蛋白hENT1的甘氨酸154对于核苷转运以及赋予对抑制剂硝基苄硫肌苷、双嘧达莫和地拉齐普的敏感性很重要。
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Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy.从恶性疟原虫中鉴定出一种核苷/核碱基转运蛋白，这是抗疟疾化疗的一个新靶点。
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Inhibition of glucose uptake in murine cardiomyocyte cell line HL-1 by cardioprotective drugs dilazep and dipyridamole.具有心脏保护作用的药物地拉卓和双嘧达莫对小鼠心肌细胞系HL-1葡萄糖摄取的抑制作用。
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[3H]dipyridamole binding to nucleoside transporters from guinea-pig and rat lung.[3H]双嘧达莫与豚鼠和大鼠肺核苷转运体的结合
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