Cornelius J R, Schulz S C, Brenner R P, Soloff P H, Ulrich R F
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213.
Biol Psychiatry. 1988 Sep;24(5):587-94. doi: 10.1016/0006-3223(88)90169-2.
Recent authors have hypothesized that cerebral dysfunction, as reflected in an abnormal EEG, may play an important role in the behavioral symptoms of patients with borderline personality disorder (BPD). Spectral analysis and amphetamine challenge testing are two promising methods for probing the clinical symptomatology of this disorder. In this study, we evaluated the relationship between clinical symptoms and computerized EEG spectral analysis in BPD patients both before and after amphetamine challenge. We found that mean frequency values on spectral analysis consistently correlated with anxiety levels in our patients, but did not correlate with a wide variety of other important symptoms, such as depression or transient psychosis. This result, coupled with our previous negative findings concerning EEG abnormalities in patients with BPD, casts doubt on the etiological relationship of cerebral dysrhythmias to the behavioral pathology of this disorder, but raises interesting questions concerning the relationship of anxiety and mean frequency.
近期的研究者推测，脑电图异常所反映的大脑功能障碍，可能在边缘型人格障碍（BPD）患者的行为症状中起重要作用。频谱分析和苯丙胺激发试验是探究该障碍临床症状的两种有前景的方法。在本研究中，我们评估了BPD患者在苯丙胺激发前后临床症状与计算机化脑电图频谱分析之间的关系。我们发现，频谱分析中的平均频率值始终与患者的焦虑水平相关，但与多种其他重要症状，如抑郁或短暂性精神病无关。这一结果，再加上我们之前关于BPD患者脑电图异常的阴性发现，让人对脑节律异常与该障碍行为病理学之间的病因关系产生怀疑，但也引发了关于焦虑与平均频率关系的有趣问题。
