脂肪干细胞转染治疗山羊手术诱导性骨关节炎。
-, -Transfected Adipose Stem Cells to Treat Surgically-Induced Osteoarthritis in Goats.
机构信息
1Research Institute for Integrative Regenerative Biomedical Engineering, Dongguk University, Goyang-si, Republic of Korea.
2Research and Development Institute, Biosolution Co., Ltd., Seoul, Republic of Korea.
出版信息
Tissue Eng Part A. 2019 Jul;25(13-14):990-1000. doi: 10.1089/ten.TEA.2018.0189. Epub 2019 Jan 30.
We developed -, -transfected human adipose stem cells (ASCs) to treat osteoarthritis (OA). -, -transfection led to chondrogenesis of adipose stem cells (ASCs) comparable to that achieved by growth factor treatment. Intra-articular injection of -, -transfected ASCs reduced the progression of surgically-induced OA in goats. tracking of transfected cell suggested paracrine mode of action. We think that -, -transfected ASC provides a novel potential strategy for the treatment of OA.
我们通过转染 -/- 基因的方法构建了人脂肪间充质干细胞（ASCs），以治疗骨关节炎（OA）。转染 -/- 基因能够诱导脂肪间充质干细胞（ASCs）向软骨细胞分化，其效果与生长因子治疗相当。关节内注射转染后的 ASCs 能够减缓山羊手术诱导型 OA 的进展。转染细胞的示踪表明其发挥作用的方式可能为旁分泌。我们认为转染 -/- 基因的 ASC 为 OA 的治疗提供了一种新的潜在策略。
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