Flueggeacosines A-C，二聚 securinine 型生物碱类似物，具有神经元分化活性，来自于醉鱼草。
Flueggeacosines A-C, Dimeric Securinine-Type Alkaloid Analogues with Neuronal Differentiation Activity from Flueggea suffruticosa.
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China.
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.
出版信息
Org Lett. 2018 Dec 7;20(23):7703-7707. doi: 10.1021/acs.orglett.8b03432. Epub 2018 Nov 28.
Flueggeacosines A-C (1-3), three dimeric securinine-type alkaloid analogues with unprecedented skeletons, were isolated from Flueggea suffruticosa. Compounds 1 and 2 are the first examples of C-3-C-15' connected dimeric securinine-type alkaloids. Compound 3 is an unprecedented heterodimer of securinine-type and benzoquinolizidine alkaloids. Biosynthetic pathways for 1-3 were proposed on the basis of the coexisting alkaloid monomers as the precursors. Compound 2 exhibited significant activity in promoting neuronal differentiation of Neuro-2a cells.
Flueggeacosines A-C（1-3），三种二聚体 securinine 型生物碱类似物，具有前所未有的骨架，从 Flueggea suffruticosa 中分离得到。化合物 1 和 2 是首例 C-3-C-15' 连接的二聚体 securinine 型生物碱。化合物 3 是 securinine 型和苯并喹啉型生物碱的前所未有的杂二聚体。基于共存的生物碱单体作为前体，提出了 1-3 的生物合成途径。化合物 2 对促进 Neuro-2a 细胞的神经元分化具有显著活性。
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