哺乳动物细胞的负π介子辐照。II. 暴露于π介子和钴γ射线后细胞周期进程的比较分析。

Negative pion irradiation of mammalian cells. II. A comparative analysis of cell-cycle progression after exposure to pi-mesons and cobalt gamma-rays.

作者信息

Schlag H, Weibezahn K F, Lücke-Huhle C

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Jan;33(1):1-10. doi: 10.1080/09553007714551441.

Abstract

The effect of negative pi-mesons on cell-cycle progression of exponentially-growing V 79 monolayer cultures was examined by flow-microfluorometric analysis. Comparison with proliferative changes of the same cell-line after cobalt gamma-irradiation yielded r.b.e. values (relative biological effectiveness) of 2.2 for both, G2+M accumulation and division delay after irradiation at the pion peak. A dose-dependent prolongation of S-phase was found after Co gamma-irradiation which, however, was not detectable after pi-exposure. This observation is so far the only qualitative difference demonstrated in the effects of the two types of radiation.

摘要

通过流式微量荧光分析研究了负π介子对指数生长的V 79单层培养细胞周期进程的影响。将其与钴γ射线照射后同一细胞系的增殖变化进行比较，在π介子峰值照射后，G2 + M期积累和分裂延迟的相对生物效应（r.b.e.）值均为2.2。钴γ射线照射后发现S期呈剂量依赖性延长，然而，π介子照射后未检测到这种情况。迄今为止，这一观察结果是这两种辐射效应中唯一显示出的定性差异。