Lapidot T, Singer T S, Reisner Y
Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel.
Bone Marrow Transplant. 1988 Mar;3(2):157-64.
C3H/HeJ mice were exposed to 8 or 9 Gy total body irradiation prior to transplantation of 1-15 x 10(6) H-2 incompatible T cell-depleted bone marrow cells from C57BL/6 donors. Survival was greatly enhanced compared to irradiated controls, even at the lowest cell doses. Analysis of spleen cells 1-7 weeks post-transplant revealed that recipients of the lowest doses of T cell-depleted bone marrow had only transient engraftment of donor type cells, and that long-term recovery was autologous. This transient engraftment had a marked beneficial effect both on reconstitution of hematopoiesis and on survival.
在移植来自C57BL/6供体的1 - 15×10⁶个H - 2不相容的T细胞去除的骨髓细胞之前，将C3H/HeJ小鼠暴露于8或9 Gy的全身照射。与照射对照组相比，即使在最低细胞剂量下，存活率也大大提高。移植后1 - 7周对脾细胞的分析显示，接受最低剂量T细胞去除骨髓的受体仅短暂植入供体类型细胞，并且长期恢复是自体的。这种短暂植入对造血重建和存活均具有显著的有益作用。
