Fraunhofer-Institut für Biomedizinische Technik (IBMT), Department of Biomedical Microsystems, 66280 Sulzbach/Saar, Germany.
ITAP, Universidad de Valladolid, Paseo del Cauce 59, 47011 Valladolid, Spain.
Sensors (Basel). 2018 Nov 27;18(12):4152. doi: 10.3390/s18124152.
The design of safe stimulation protocols for functional electrostimulation requires knowledge of the "maximum reversible charge injection capacity" of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access voltage . This paper proposes a method to calculate that does not require prior knowledge of the overpotential terms and of the electrolyte (or excitable tissue) resistance, which is an advantage for in vivo electrochemical characterization of microelectrodes. To validate this method, we compare the calculated results with those obtained from conventional methods for characterizing three flexible platinum microelectrodes by cyclic voltammetry and voltage transient measurements. This paper presents the experimental setup, the required instrumentation, and the signal processing.
安全刺激协议的设计对于功能性电刺激来说，需要了解可植入微电极的“最大可逆电荷注入容量”。在对这种微电极进行特性描述时遇到的主要困难之一是计算接入电压。本文提出了一种计算接入电压的方法，该方法不需要预先知道过电势项和电解质（或可兴奋组织）电阻，这对于微电极的体内电化学特性描述是一个优势。为了验证这种方法，我们通过循环伏安法和电压瞬态测量对三种柔性铂微电极进行特性描述，将计算结果与传统方法的结果进行比较。本文介绍了实验设置、所需的仪器设备和信号处理。
