Bai Dong, Yue Guang-Xin, Wang Rui-Hai, Miao Qing, Xu Jing, Liu Li-Mei
Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2018 Oct;43(20):4152-4162. doi: 10.19540/j.cnki.cjcmm.20180709.002.
In this article, we analyze the clinical characteristics of five kinds of traditional Chinese medicine injections in treating heart failure based on Meta-analysis. A total of 24 Meta-analysis papers were included, which involved Shenfu Injection, Shenmai Injection, Shengmai Injection, Danhong Injection and Huangqi Injection. The numbers of literatures of Shenfu Injection, Shenmai Injection and Shengmai Injection are high than the other two injections. The efficiencies of these injections combined with Western medicine are higher than the Western medicine used alone. They can improve 6 minute walk test result, ejection fraction, the level of brain peptide sodium and so on. Shenfu Injection can also improve the living quality of patients' life, heart rate and other indicators. Shenfu Injection can be used for patients with Yin deficiency, while Shenmai Injection can be used for patients with Yin deficiency and Shengmai Injection can be used for patients with Qi and Yin deficiency. From this information, we can see that Western medicine combined with traditional Chinese medicine injections can significantly improve the clinical efficiency. These injections need to be used according to patients' symptom. In the present, as the quality of clinical research literature of traditional Chinese medicine injections is low, the efficiency and safety evaluation of Chinese medicine injections still requires higher level of clinical evidence.
在本文中,我们基于Meta分析来剖析五种中药注射剂治疗心力衰竭的临床特征。共纳入24篇Meta分析论文,涉及参附注射液、参麦注射液、生脉注射液、丹红注射液和黄芪注射液。参附注射液、参麦注射液和生脉注射液的文献数量多于其他两种注射剂。这些注射剂与西药联合使用的疗效高于单纯使用西药。它们可以改善6分钟步行试验结果、射血分数、脑钠肽水平等。参附注射液还可改善患者生活质量、心率等指标。参附注射液可用于阴虚患者,参麦注射液可用于阴虚患者,生脉注射液可用于气阴两虚患者。由此可知,西药联合中药注射剂可显著提高临床疗效。这些注射剂需根据患者症状使用。目前,由于中药注射剂临床研究文献质量较低,中药注射剂的疗效和安全性评价仍需要更高水平的临床证据。