特纳综合征患者自身免疫性甲状腺疾病的患病率：横断面研究的荟萃分析
Prevalence of autoimmune thyroid diseases among the Turner Syndrome patients: meta-analysis of cross sectional studies.
作者信息
Mohamed Sagad Omer Obeid, Elkhidir Ibrahim Hassan Eldaw, Abuzied Abdelhamid Ibrahim Hassan, Noureddin Ahmed Abdulgadir Mohammed Hassan, Ibrahim Gehad Abdelmonem Abdalla, Mahmoud Ahmed Abdallah Ali
机构信息
Faculty of Medicine, University of Khartoum, Qasr Street, P.O. Box 11111, Khartoum, Sudan.
出版信息
BMC Res Notes. 2018 Nov 29;11(1):842. doi: 10.1186/s13104-018-3950-0.
OBJECTIVE
This meta-analysis was done to estimate the prevalence of autoimmune thyroid diseases (ATDs) in Turner Syndrome patients, and to determine the clinical status of thyroid autoimmune diseases that occur frequently in association with Turner Syndrome.
RESULTS
A total of 18 studies were included in the meta-analysis. The pooled overall prevalence of autoimmune thyroid diseases in Turner Syndrome patients was 38.6% (95% CI 29.7-47.6%), with 12.7% (95% CI 9.30-16.1%) of them had clinical hypothyroidism and 2.6% (95% CI 1.5-3.8%) had hyperthyroidism. I-squared test had a high result of heterogeneity. In subgroup analyses, the prevalence of ATDs was higher in the European region than Asian region. Autoimmune thyroid diseases are commonly associated with Turner Syndrome. Early detection of thyroid diseases by optimal screening among children with Turner Syndrome is required to ensure effective management.
目的
本荟萃分析旨在估计特纳综合征患者自身免疫性甲状腺疾病（ATD）的患病率，并确定与特纳综合征经常相关的甲状腺自身免疫性疾病的临床状况。
结果
荟萃分析共纳入18项研究。特纳综合征患者自身免疫性甲状腺疾病的合并总体患病率为38.6%（95%可信区间29.7 - 47.6%），其中12.7%（95%可信区间9.30 - 16.1%）有临床甲状腺功能减退，2.6%（95%可信区间1.5 - 3.8%）有甲状腺功能亢进。I²检验显示异质性结果较高。在亚组分析中，欧洲地区ATD的患病率高于亚洲地区。自身免疫性甲状腺疾病通常与特纳综合征相关。需要通过对特纳综合征患儿进行最佳筛查来早期发现甲状腺疾病，以确保有效管理。
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