Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, , Oxford, UK.
Arch Dis Child. 2014 Jan;99(1):71-3. doi: 10.1136/archdischild-2013-304617. Epub 2013 Sep 24.
There is increasing evidence that Turner syndrome is associated with an elevated risk of a range of autoimmune disorders. We aimed to document this in a national study.
Use of a record-linked dataset of all hospital admissions in England, 1999-2011, to construct a retrospective cohort of people with Turner syndrome and a control cohort of people without it. Statistical follow-up to identify the occurrence of 29 separate autoimmune disorders in each cohort. Calculation of rate ratios, comparing the Turner and control cohorts.
In the Turner syndrome cohort (2459 people), rate ratios were elevated for 16 of the 29 conditions. Examples included coeliac disease (rate ratio 14.0, 95% CI 10.2 to 18.8), Crohn's disease (5.3, 3.5 to 7.8), ulcerative colitis (3.9, 2.3 to 6.1), hypothyroidism (8.8, 7.8 to 9.9) and hyperthyroidism (4.9, 3.2 to 7.1).
The increased risk of autoimmune disorders in people with Turner syndrome covers a wide range of conditions.
越来越多的证据表明特纳综合征与一系列自身免疫性疾病的风险增加有关。我们旨在通过一项全国性研究来记录这一点。
利用英格兰 1999 年至 2011 年所有住院患者的记录链接数据集，构建特纳综合征患者的回顾性队列和无特纳综合征患者的对照组。对每个队列进行统计随访，以确定 29 种不同的自身免疫性疾病的发生情况。计算率比，比较特纳综合征组和对照组。
在特纳综合征组（2459 人）中，29 种疾病中有 16 种的比率升高。例如，乳糜泻（比值比 14.0，95%置信区间 10.2 至 18.8）、克罗恩病（5.3，3.5 至 7.8）、溃疡性结肠炎（3.9，2.3 至 6.1）、甲状腺功能减退症（8.8，7.8 至 9.9）和甲状腺功能亢进症（4.9，3.2 至 7.1）。
特纳综合征患者自身免疫性疾病的风险增加涵盖了广泛的疾病。
