Freij Jenny M, Burton Hanna E, Espino Daniel M
Department of Mechanical Engineering, University of Birmingham, Birmingham, B15 2TT, UK.
Cardiovasc Eng Technol. 2019 Mar;10(1):61-68. doi: 10.1007/s13239-018-00395-x. Epub 2018 Nov 28.
This study aimed to develop an objective method for the elastic characterisation of pre- and post-transitional moduli of left anterior descending (LAD) porcine coronary arteries.
Eight coronary arteries were divided into proximal, middle and distal test specimens. Specimens underwent uniaxial extension up to 3 mm. Force-displacement measurements were used to determine the induced true stress and stretch for each specimen. A local maximum of the stretch-true stress data was used to identify a transition point. Pre- and post-transitional moduli were calculated up to and from this point, respectively.
The mean pre-transitional moduli for all specimens was 0.76 MPa, as compared to 4.86 MPa for the post-transitional moduli. However, proximal post-transitional moduli were significantly greater than that of middle and distal test specimens (p < 0.05).
Post-transitional uniaxial properties of the LAD are dependent on location along the artery. Further, it is feasible to objectively identify a transition point between pre- and post-transitional moduli.
本研究旨在开发一种客观方法，用于对猪左前降支（LAD）冠状动脉过渡前和过渡后的弹性模量进行表征。
将八条冠状动脉分为近端、中段和远端测试样本。样本进行单轴拉伸至3毫米。通过力-位移测量来确定每个样本所产生的真实应力和应变。利用拉伸-真实应力数据的局部最大值来确定一个过渡点。分别从此点之前和之后计算过渡前和过渡后的模量。
所有样本的平均过渡前模量为0.76兆帕，而过渡后模量为4.86兆帕。然而，近端过渡后模量显著大于中段和远端测试样本（p < 0.05）。
LAD的过渡后单轴特性取决于沿动脉的位置。此外，客观识别过渡前和过渡后模量之间的过渡点是可行的。
