Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
J Neurochem. 2019 May;149(3):317-330. doi: 10.1111/jnc.14637. Epub 2019 Jan 15.
It remains unclear whether biomarkers in the serum or CSF can be used for diagnosis or prognosis of spinal cord injuries (SCI). Therefore, a systematic review was undertaken to evaluate the prognostic or diagnostic value of serum and CSF biomarkers in assessing the severity of SCI and the outcome of patients. Two independent reviewers summarized the human studies retrieved from the electronic databases of Medline, Embase, Scopus and ISI Web of Science until April 2018. Seventeen studies were included (1065 patients aged 16-94 years old). Although the findings of the included studies suggest that inflammatory and structural proteins may be useful in assessing the severity of SCI and prediction of neurological outcome, the level of evidence is generally low. Given limitations to the available evidence, further investigation in this field is required using large prospective data sets with rigorous analysis of sensitivity, specificity and prediction.
目前尚不清楚血清或脑脊液中的生物标志物是否可用于诊断或预测脊髓损伤 (SCI)。因此，进行了一项系统评价，以评估血清和脑脊液生物标志物在评估 SCI 严重程度和患者预后方面的预测或诊断价值。两位独立的综述者总结了从 Medline、Embase、Scopus 和 ISI Web of Science 电子数据库中检索到的人类研究，截至 2018 年 4 月。共纳入 17 项研究（1065 名年龄在 16-94 岁的患者）。尽管纳入研究的结果表明，炎症和结构蛋白可能有助于评估 SCI 的严重程度和预测神经功能结局，但证据水平普遍较低。鉴于现有证据的局限性，需要使用具有严格分析敏感性、特异性和预测性的大型前瞻性数据集进一步研究该领域。
