Assessment of S values for I and Y based on the Digimouse voxel phantom.

INTRODUCTION

Most preclinical studies using radiopharmaceuticals have been carried out on mice. In nuclear medicine and radioimmunotherapy procedures, I and Y have been widely used. For better estimation of doses from these procedures, S value plays a vital role. In this study, we have evaluated S values for major source and target combinations of Digimouse voxel phantom.

MATERIALS AND METHODS

We have used the Digimouse voxel phantom which was incorporated in Monte Carlo code FLUKA. Simulation studies were performed using Monte Carlo simulation code FLUKA. Latest publication of International Commission on Radiological Protection (ICRP) report 110 was used for assigning the values of organ compositions and densities. Photon and electron spectra for I and Y have been taken from the ICRP publication 107. For Digimouse voxel phantom, we have simulated 9 source regions with an assumed uniform distribution of I and Y.

RESULTS AND DISCUSSION

S values have been evaluated for I and Y for different source and target combinations of Digimouse voxel phantom and presented in tabular form. The S values can be applied prospectively or retrospectively to the calculation of radiation doses internally exposed to I and Y, including nuclear medicine and radioimmunotherapy procedures. These S values have been very important for the calculation of absorbed doses for various organs similar in size to present study for mice.

CONCLUSION

In this study S value for I and Y were evaluated for major organs of digimouse voxel phantom. These S values are very important for absorbed dose calculation for various organs of a mouse.